Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine

被引：6

作者：

Goda, Ken ^{[1
,2
]}

Kenzaka, Tsuneaki ^{[1
,2
]}

Yahata, Shinsuke ^{[3
]}

Okayama, Masanobu ^{[4
]}

Nishisaki, Hogara ^{[1
]}

机构：

[1] Hyogo Prefectural Tamba Med Ctr, Dept Internal Med, Tamba 6693495, Japan

[2] Kobe Univ, Div Community Med & Career Dev, Grad Sch Med, 2-1-5 Arata Cho, Kobe, Hyogo 6520032, Japan

[3] Hyogo Prefectural HarimaHimeji Gen Med Ctr, Dept Gen Internal Med, 3-264 Kamiya Cho, Himeji 6708560, Japan

[4] Kobe Univ, Div Community Med & Med Educ, Grad Sch Med, 2-1-5 Arata Cho, Kobe, Hyogo 6520032, Japan

来源：

VACCINES | 2022年 / 10卷 / 08期

关键词：

COVID-19; vaccine; adverse reactions; first dose; second dose; SAFETY;

D O I：

10.3390/vaccines10081232

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study investigated the frequency of adverse reactions to COVID-19 vaccines in Japan and the impact of first-dose adverse reactions on second-dose adverse reactions. Individuals who received an mRNA COVID-19 vaccine at our center in March or April 2021 were included. Data were collected using questionnaires. The main factors were age (<40, 40-59, and >60 years), sex, underlying disease, and first-dose adverse reaction. The primary outcomes were incidence of local and systemic adverse reactions (ARs) attributable to the vaccine. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Among 671 participants, 90% experienced local or systemic ARs. An AR to the first dose was associated with a significantly increased risk of an AR to the second dose (OR: 49.63, 95% CI: 21.96-112.16). ARs were less common among men than among women (OR: 0.36, 95% CI: 0.17-0.76). Local ARs were less common among those aged 60 years or older (OR: 0.35, 95% CI: 0.18-0.66), whereas systemic ARs were more common among those aged under 40 years. Information on ARs to the first dose is important for healthcare providers and recipients when making vaccination decisions.

引用

页数：11

共 21 条

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