Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma

被引：63

作者：

Uehara, M ^{[1
]}

Sano, K

Ikeda, H

Sekine, J

Irie, A

Yokota, T

Tobita, T

Ohba, S

Inokuchi, T

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Dev & Reconstruct Med, Div Oral & Maxillofacial Surg Reconstruct & Funct, Nagasaki 8528588, Japan

[2] Fukui Med Univ, Dept Dent & Oral Surg, Fukui 9101193, Japan

来源：

ORAL ONCOLOGY | 2004年 / 40卷 / 03期

关键词：

vascular endothelial growth factor; oral squamous cell carcinoma; prognosis;

D O I：

10.1016/j.oraloncology.2003.08.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The correlation between expression of vascular endothelial growth factor (VEGF) and prognosis for oral squamous cell carcinoma was investigated. Tissue samples of oral squamous cell carcinoma were obtained from 63 patients. Of these patients, 11 had stage I, 17 had stage I, 9 had stage III, and 26 had stage IV turnours. Immunohistochemical expression of VEGF was quantitatively determined by computer-assisted image analysis. The value of VEGF expression was significantly higher for the patients with poor prognosis than for those with good prognosis (P=0.0423). Regarding regional lymph node metastasis, VEGF showed no significant difference between metastasis positive and negative patients. Expression of VEGF may thus be a prognostic marker for oral squamous cell carcinoma. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：321 / 325

页数：5

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