Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women

被引：7

作者：

Petkus, Andrew J. ^{[1
]}

Younan, Diana ^{[2
]}

Wang, Xinhui ^{[1
]}

Beavers, Daniel P. ^{[3
]}

Espeland, Mark A. ^{[3
]}

Gatz, Margaret ^{[4
]}

Gruenewald, Tara ^{[5
]}

Kaufman, Joel D. ^{[6
]}

Chui, Helena C. ^{[1
]}

Millstein, Joshua ^{[2
]}

Rapp, Stephen R. ^{[7
]}

Manson, JoAnn E. ^{[8
]}

Resnick, Susan M. ^{[9
]}

Wellenius, Gregory A. ^{[10
]}

Whitsel, Eric A. ^{[11
,12
]}

Widaman, Keith ^{[13
]}

Chen, Jiu-Chiuan ^{[1
,2
]}

机构：

[1] Univ Southern Calif, Dept Neurol, 1520 San Pablo St,Suite 3000, Los Angeles, CA 90033 USA

[2] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90033 USA

[3] Wake Forest Sch Med, Dept Biostat, Winston Salem, NC 27101 USA

[4] Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90033 USA

[5] Chapman Univ, Dept Psychol, Orange, CA USA

[6] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[7] Wake Forest Sch Med, Dept Psychiat & Behav Med, Winston Salem, NC 27101 USA

[8] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[9] NIA, Lab Behav Neurosci, Baltimore, MD 21224 USA

[10] Boston Univ, Dept Environm Hlth, Boston, MA 02215 USA

[11] Univ N Carolina, Dept Epidemiol, Chapel Hill, MA 27515 USA

[12] Univ N Carolina, Dept Med, Chapel Hill, MA 27515 USA

[13] Univ Calif Riverside, Grad Sch Educ, Riverside, CA 92521 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 84卷 / 04期

关键词：

Cognitive aging; latent class analysis; nitrogen dioxide; particulate matter; women; CROSS-SECTIONAL ANALYSIS; TRAFFIC NOISE EXPOSURES; ALZHEIMERS-DISEASE; PM2.5; EXPOSURE; VERBAL FLUENCY; DEMENTIA; IMPAIRMENT; SUBGROUPS; ADULTS;

D O I：

10.3233/JAD-210518

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Elucidating associations between exposures to ambient air pollutants and profiles of cognitive performance may provide insight into neurotoxic effects on the aging brain. Objective: We examined associations between empirically derived profiles of cognitive performance and residential concentrations of particulate matter of aerodynamic diameter < 2.5 (PM2.5) and nitrogen dioxide (NO2) in older women. Method: Women (N= 2,142) from the Women's Health Initiative Study of Cognitive Aging completed a neuropsychological assessment measuring attention, visuospatial, language, and episodic memory abilities. Average yearly concentrations of PM2.5 and NO2 were estimated at the participant's addresses for the 3 years prior to the assessment. Latent profile structural equation models identified subgroups of women exhibiting similar profiles across tests. Multinomial regressions examined associations between exposures and latent profile classification, controlling for covariates. Result: Five latent profiles were identified: low performance across multiple domains (poor multi-domain; n= 282;13%), relatively poor verbal episodic memory (poor memory; n= 216; 10%), average performance across all domains (average multi-domain; n= 974; 45%), superior memory (n=381; 18%), and superior attention (n=332; 15%). Using women with average cognitive ability as the referent, higher PM2.5 (per interquartile range [IQR] = 3.64 mu g/m(3)) was associated with greater odds of being classified in the poor memory (OR =1.29; 95% Confidence Interval [CI] =1.10-1.52) or superior attention (OR =1.30; 95%CI= 1.10-1.53) profiles. NO2 (per IQR = 9.86 ppb) was associated with higher odds of being classified in the poor memory (OR =1.38; 95% CI =1.17-1.63) and lower odds of being classified with superior memory (OR = 0.81; 95% CI = 0.67-0.97). Conclusion: Exposure to PM2.5 and NO2 are associated with patterns of cognitive performance characterized by worse verbal episodic memory relative to performance in other domains.

引用

页码：1691 / 1707

页数：17

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