Stem Cell Based Cancer Gene Therapy

被引：79
作者：
Cihova, Marina [1 ]
Altanerova, Veronika [1 ]
Altaner, Cestmir [1 ]
机构：
[1] Slovak Acad Sci, Canc Res Inst, Mol Oncol Lab, Bratislava 83391, Slovakia
来源：
MOLECULAR PHARMACEUTICS | 2011年 / 8卷 / 05期
关键词：
mesenchymal stem cells; prodrug enzymes; cytosine deaminase; HSVtk; suicide gene therapy; immunostimulation; MESENCHYMAL STROMAL CELLS; MALIGNANT GLIOMA; TARGETED-DELIVERY; TUMOR STROMA; C6; GLIOMA; IN-VIVO; BRAIN; VEHICLES; MIGRATION; GROWTH;
D O I：
10.1021/mp200151a
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The attractiveness of prodrug cancer gene therapy by stem cells targeted to tumors lies in activating the prodrug directly within the tumor mass, thus avoiding systemic toxicity. Suicide gene therapy using genetically engineered mesenchymal stem cells has the advantage of being safe, because prodrug administration not only eliminates tumor cells but consequently kills the more resistant therapeutic stem cells as well. This review provides an explanation of the stem cell-targeted prodrug cancer gene therapy principle, with focus on the choice of prodrug, properties of bone marrow and adipose tissue-derived mesenchymal stem and neural stem cells as well as the mechanisms of their tumor homing ability. Therapeutic achievements of the cytosine deaminase/S-fluorocytosine prodrug system and Herpes simplex virus thymidine kinase/ganciclovir are discussed. In addition, delivery of immunostimulatory cytokines, apoptosis inducing genes, nanoparticles and antiangiogenic proteins by stem cells to tumors metastases is discussed as a promising approach for antitumor therapy. Combinations of traditional, targeted and stem cell-directed gene therapy could significantly advance the treatment of cancer.
引用
收藏
页码：1480 / 1487
页数：8
相关论文
共 78 条
[1]   Development of a Tumor-Selective Approach to Treat Metastatic Cancer [J].
Aboody, Karen S. ;
Bush, Rebecca A. ;
Garcia, Elizabeth ;
Metz, Marianne Z. ;
Najbauer, Joseph ;
Justus, Kristine A. ;
Phelps, Doris A. ;
Remack, Joanna S. ;
Yoon, Karina Jin ;
Gillespie, Shanna ;
Kim, Seung U. ;
Glackin, Carlotta A. ;
Potter, Philip M. ;
Danks, Mary K. .
PLOS ONE, 2006, 1 (01)
[2]   Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].
Aboody, KS ;
Brown, A ;
Rainov, NG ;
Bower, KA ;
Liu, SX ;
Yang, W ;
Small, JE ;
Herrlinger, U ;
Ourednik, V ;
Black, PM ;
Breakefield, XO ;
Snyder, EY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851
[3]   Targeting of melanoma brain metastases using engineered neural stem/progenitor cells [J].
Aboody, KS ;
Najbauer, J ;
Schmidt, NO ;
Yang, W ;
Wu, JK ;
Zhuge, Y ;
Przylecki, W ;
Carroll, R ;
Black, PM ;
Perides, G .
NEURO-ONCOLOGY, 2006, 8 (02) :119-126
[4]   Prodrug cancer gene therapy [J].
Altaner, Cestmir .
CANCER LETTERS, 2008, 270 (02) :191-201
[5]  
ALTANEROVA V, 2011, INT J CANC IN PRESS
[6]   Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy [J].
Amano, Shinji ;
Li, Shaoyi ;
Gu, Chunyu ;
Gao, Yun ;
Koizumi, Shinichiro ;
Yamamoto, Seiji ;
Terakawa, Susumu ;
Namba, Hiroki .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 35 (06) :1265-1270
[7]   Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy [J].
Bak, X. Y. ;
Yang, J. ;
Wang, S. .
CANCER GENE THERAPY, 2010, 17 (10) :721-729
[8]   Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors [J].
Bergers, G ;
Song, S ;
Meyer-Morse, N ;
Bergsland, E ;
Hanahan, D .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) :1287-1295
[9]   Toward Brain Tumor Gene Therapy Using Multipotent Mesenchymal Stromal Cell Vectors [J].
Bexell, Daniel ;
Scheding, Stefan ;
Bengzon, Johan .
MOLECULAR THERAPY, 2010, 18 (06) :1067-1075
[10]   Bone Marrow Multipotent Mesenchymal Stroma Cells Act as Pericyte-like Migratory Vehicles in Experimental Gliomas [J].
Bexell, Daniel ;
Gunnarsson, Salina ;
Tormin, Ariane ;
Darabi, Anna ;
Gisselsson, David ;
Roybon, Laurent ;
Scheding, Stefan ;
Bengzon, Johan .
MOLECULAR THERAPY, 2009, 17 (01) :183-190
12345678