Cerebrospinal fluid τ and β-amyloid(I-42) in dementia disorders

被引：47
|
作者：
Vanmechelen, E
Vanderstichele, H
Hulstaert, F
Andreasen, N
Minthon, L
Winblad, B
Davidsson, P
Blennow, K
机构：
[1] Innogenet NV, B-9052 Ghent, Belgium
[2] Pitea River Valley Hosp, Dept Rehabil, Pitea, Sweden
[3] Malmo Univ Hosp, Neuropsychiat Clin, Dept Clin Neurosci, Malmo, Sweden
[4] Karolinska Inst, Huddinge Univ Hosp, Geriatr Med Sect, Dept Clin Neurosci & Family Med, S-10521 Stockholm, Sweden
[5] Univ Gothenburg, Unit Neurochem, Dept Clin Neurosci, S-41320 Gothenburg, Sweden
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 16期
关键词：
cerebrospinal fluid; iota; beta-amyloid; Alzheimer's disease; dementia; diagnosis;
D O I：
10.1016/S0047-6374(01)00304-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta -amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD. (C) 2001 Elsevier Science Ireland Ltd, All rights reserved.
引用
收藏
页码：2005 / 2011
页数：7
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