Cerebrospinal fluid τ and β-amyloid(I-42) in dementia disorders

被引：47
|
作者：
Vanmechelen, E
Vanderstichele, H
Hulstaert, F
Andreasen, N
Minthon, L
Winblad, B
Davidsson, P
Blennow, K
机构：
[1] Innogenet NV, B-9052 Ghent, Belgium
[2] Pitea River Valley Hosp, Dept Rehabil, Pitea, Sweden
[3] Malmo Univ Hosp, Neuropsychiat Clin, Dept Clin Neurosci, Malmo, Sweden
[4] Karolinska Inst, Huddinge Univ Hosp, Geriatr Med Sect, Dept Clin Neurosci & Family Med, S-10521 Stockholm, Sweden
[5] Univ Gothenburg, Unit Neurochem, Dept Clin Neurosci, S-41320 Gothenburg, Sweden
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 16期
关键词：
cerebrospinal fluid; iota; beta-amyloid; Alzheimer's disease; dementia; diagnosis;
D O I：
10.1016/S0047-6374(01)00304-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta -amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD. (C) 2001 Elsevier Science Ireland Ltd, All rights reserved.
引用
收藏
页码：2005 / 2011
页数：7
相关论文
共 50 条
  • [1] Amyloid Pathology Influences Aβ1-42 Cerebrospinal Fluid Levels in Dementia with Lewy Bodies
    Slaets, Sylvie
    Le Bastard, Nathalie
    Theuns, Jessie
    Sleegers, Kristel
    Verstraeten, Aline
    De Leenheir, Evelyn
    Luyckx, Jill
    Martin, Jean-Jacques
    Van Broeckhoven, Christine
    Engelborghs, Sebastiaan
    JOURNAL OF ALZHEIMERS DISEASE, 2013, 35 (01) : 137 - 146
  • [2] Amyloid beta 1-42 in cerebrospinal fluid is associated with cognitive plasticity
    Uttner, Ingo
    Schurig, Niklas
    von Arnim, Christine A. F.
    Lange-Asschenfeldt, Christian
    Brettschneider, Johannes
    Riepe, Matthias W.
    Tumani, Hayrettin
    PSYCHIATRY RESEARCH, 2011, 190 (01) : 132 - 136
  • [3] Brain Metabolic Correlates of Cerebrospinal Fluid Beta-Amyloid 42 and Tau in Alzheimer's Disease
    Vukovich, Ruth
    Perneczky, Robert
    Drzezga, Alexander
    Foerstl, Hans
    Kurz, Alexander
    Riemenschneider, Matthias
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2009, 27 (05) : 474 - 480
  • [4] Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer's, but not in frontotemporal dementia
    Bibl, Mirko
    Gallus, Marion
    Welge, Volker
    Esselmann, Hermann
    Wolf, Stefanie
    Ruether, Eckart
    Wiltfang, Jens
    JOURNAL OF NEURAL TRANSMISSION, 2012, 119 (07) : 805 - 813
  • [5] Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia
    Skillback, Tobias
    Farahmand, Bahman Y.
    Rosen, Christoffer
    Mattsson, Niklas
    Nagga, Katarina
    Kilander, Lena
    Religa, Dorota
    Wimo, Anders
    Winblad, Bengt
    Schott, Jonathan M.
    Blennow, Kaj
    Eriksdotter, Maria
    Zetterberg, Henrik
    BRAIN, 2015, 138 : 2716 - 2731
  • [6] Correlation of florbetaben PET imaging and the amyloid peptide Aβ42 in cerebrospinal fluid
    Schipke, Carola G.
    Koglin, Norman
    Bullich, Santiago
    Joachim, Lisa Katharina
    Haas, Brigitte
    Seibyl, John
    Barthel, Henryk
    Sabri, Osama
    Peters, Oliver
    PSYCHIATRY RESEARCH-NEUROIMAGING, 2017, 265 : 98 - 101
  • [7] Neprilysin Activity in Cerebrospinal Fluid is Associated with Dementia and Amyloid-β42 Levels in Lewy Body Disease
    Maetzler, Walter
    Stoycheva, Velichka
    Schmid, Benjamin
    Schulte, Claudia
    Hauser, Ann-Kathrin
    Brockmann, Kathrin
    Melms, Arthur
    Gasser, Thomas
    Berg, Daniela
    JOURNAL OF ALZHEIMERS DISEASE, 2010, 22 (03) : 933 - 938
  • [8] Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: A population-based study in 85-year-olds
    Skoog, I
    Davidsson, P
    Aevarsson, O
    Vanderstichele, H
    Vanmechelen, E
    Blennow, K
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2003, 15 (03) : 169 - 176
  • [9] Cerebrospinal Fluid α-Synuclein Does Not Discriminate Between Dementia Disorders
    Spies, Petra E.
    Melis, Rene J. F.
    Sjogren, Magnus J. C.
    Rikkert, Marcel G. M. Olde
    Verbeek, Marcel M.
    JOURNAL OF ALZHEIMERS DISEASE, 2009, 16 (02) : 363 - 369
  • [10] Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's Disease
    Lewczuk, Piotr
    Matzen, Anja
    Blennow, Kaj
    Parnetti, Lucilla
    Molinuevo, Jose Luis
    Eusebi, Paolo
    Kornhuber, Johannes
    Morris, John C.
    Fagan, Anne M.
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 55 (02) : 813 - 822
12345