Managing uveitis in patients with juvenile idiopathic arthritis

被引：0
作者：
Foeldvari, Ivan [1 ]
机构：
[1] Semmelweis Univ, Hamburger Zentrum Kinder & Jugendrheumatol, Lehrbereich Asklepios Campus, Budapest, Hungary
来源：
EXPERT OPINION ON ORPHAN DRUGS | 2016年 / 4卷 / 07期
关键词：
Uveitis; juvenile idiopathic arthritis; treatment; therapeutic window; methotrexate; adalimumab; infliximab; tocilizumab; rituximab; CHILDHOOD CHRONIC UVEITIS; NONINFECTIOUS UVEITIS; METAANALYSIS APPROACH; RHEUMATOID-ARTHRITIS; METHOTREXATE THERAPY; RISK-FACTORS; PREVALENCE; CHILDREN; EFFICACY; DRUGS;
D O I：
10.1080/21678707.2016.1176909
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Introduction: Juvenile idiopathic arthritis (JIA) associated uveitis is the most common extraarticular comorbidity. The management of JIA associated uveitis is still a challenge for every pediatric rheumatologist and ophthalmologist. Areas covered: This review covers the current data on systemic therapy for JIA associated uveitis. Currently, only one randomised controlled trial regarding treatment of JIA associated uveitis has been undertaken and published as full paper. A second one is available as an abstract. The review covers the current publications regarding systemic treatment of JIA associated uveitis and current suggested guidelines. Expert opinion: Despite all the current therapy options, there are patients who remain non-responders. The aim of the current treatment strategy is to target remission, using systemic therapy as early as needed to prevent any damage of JIA associated uveitis.
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收藏
页码：741 / 745
页数：5
相关论文
共 43 条
[1]   Characteristics of a cohort of children with Juvenile Idiopathic Arthritis and JIA-associated Uveitis [J].
Angeles-Han, Sheila T. ;
McCracken, Courtney ;
Yeh, Steven ;
Jenkins, Kirsten ;
Stryker, Daneka ;
Rouster-Stevens, Kelly ;
Vogler, Larry B. ;
Lambert, Scott R. ;
Drews-Botsch, Carolyn ;
Prahalad, Sampath .
PEDIATRIC RHEUMATOLOGY, 2015, 13
[2]   Risk Markers of Juvenile Idiopathic Arthritis-associated Uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry [J].
Angeles-Han, Sheila T. ;
Pelajo, Christina F. ;
Vogler, Larry B. ;
Rouster-Stevens, Kelly ;
Kennedy, Christine ;
Ponder, Lori ;
McCracken, Courtney ;
Lopez-Benitez, Jorge ;
Drews-Botsch, Carolyn ;
Prahalad, Sampath .
JOURNAL OF RHEUMATOLOGY, 2013, 40 (12) :2088-2096
[3]   Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis [J].
Bichler, J. ;
Benseler, S. M. ;
Krumrey-Langkammerer, M. ;
Haas, J-P ;
Huegle, B. .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2015, 44 (04) :280-283
[4]   Immunomodulatory therapy with tumour necrosis factor α inhibitors in children with antinuclear antibody-associated chronic anterior uveitis: long-term results [J].
Doycheva, Deshka ;
Zierhut, Manfred ;
Blumenstock, Gunnar ;
Stuebiger, Nicole ;
Januschowski, Kai ;
Voykov, Bogomil ;
Deuter, Christoph .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2014, 98 (04) :523-528
[5]   Long-term results of therapy with mycophenolate mofetil in chronic non-infectious uveitis [J].
Doycheva, Deshka ;
Zierhut, Manfred ;
Blumenstock, Gunnar ;
Stuebiger, Nicole ;
Deuter, Christoph .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2011, 249 (08) :1235-1243
[6]   Measurement of anti-drug antibodies to biologic drugs. A sexy trend-or is it clinically meaningful? [J].
Felis-Giemza, Anna ;
Moots, Robert J. .
RHEUMATOLOGY, 2015, 54 (11) :1941-1943
[7]  
Foeldvari I, 2005, J RHEUMATOL, V32, P362
[8]   Uveitis Events During Adalimumab, Etanercept, and Methotrexate Therapy in Juvenile Idiopathic Arthritis: Data From the Biologics in Pediatric Rheumatology Registry [J].
Foeldvari, Ivan ;
Becker, Ingrid ;
Horneff, Gerd .
ARTHRITIS CARE & RESEARCH, 2015, 67 (11) :1529-1535
[9]   Azathioprine as a treatment option for uveitis in patients with juvenile idiopathic arthritis [J].
Goebel, J. C. ;
Roesel, M. ;
Heinz, C. ;
Michels, H. ;
Ganser, G. ;
Heiligenhaus, A. .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2011, 95 (02) :209-213
[10]   Methotrexate for uveitis associated with juvenile idiopathic arthritis: Value and requirement for additional anti-inflammatory medication [J].
Heiligenhaus, A. ;
Mingels, A. ;
Heinz, C. ;
Ganser, G. .
EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2007, 17 (05) :743-748
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