Cuts by Caspase-14 Control the Proteolysis of Filaggrin

被引：8

作者：

Eckhart, Leopold ^{[1
]}

Tschachler, Erwin ^{[1
,2
]}

机构：

[1] Med Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria

[2] Ctr Rech & Invest Epiderm & Sensorielles, Neuilly, France

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 11期

关键词：

STRATUM-CORNEUM; DIFFERENTIATION; ACTIVATION; BREAKDOWN; BARRIER; GENE;

D O I：

10.1038/jid.2011.282

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Although mutations in the filaggrin gene (FLG) have been shown to be associated with ichthyosis vulgaris and atopic dermatitis, the function and regulation of filaggrin remain incompletely understood. In this issue, Hoste et al. report that filaggrin is directly cleaved by caspase-14. Acting in concert with other proteases, caspase-14 controls the breakdown of filaggrin to free amino acids and amino acid derivatives that contribute to the hydration and UVB absorption capacity of the stratum corneum. These findings identify a new layer of complexity in the regulation of epidermal barrier function.

引用

页码：2173 / 2175

页数：3

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