Comparison of the 3D-conformal, helical tomotherapy and multileaf collimators-based intensity modulated radiotherapy modalities using radiobiological measures

被引:0
作者
Mavroidis, P. [1 ,2 ,3 ]
Ferreira, B. Costa [1 ,2 ,4 ]
Shi, C. [5 ,6 ]
Lind, B. K. [1 ,2 ]
Papanikolaou, N. [5 ,6 ]
机构
[1] Karolinska Inst, Dept Med Radiat Phys, S-17176 Stockholm, Sweden
[2] Univ Stockholm, S-17176 Stockholm, Sweden
[3] Larissa Univ Hosp, Dept Med Phys, Larisa, Greece
[4] Univ Aveiro, Phys Dept 13N, P-3800 Aveiro, Portugal
[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiat Oncol, San Antonio, TX 78229 USA
[6] Canc Therapy & Res Ctr S Texas, Dept Med Phys, San Antonio, TX 78229 USA
来源
JOURNAL OF BUON | 2008年 / 13卷 / 01期
关键词
biologically effective uniform dose; conformal radiotherapy; complication-free tumor control; dose-response relations; helical tomotherapy; radiobiological evaluation;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Intensity modulated radiotherapy (IMRT) using multileaf collimators (MLC) and helical tomotherapy (HT) have become increasingly popular over the past few years. However their clinical efficacy and effectiveness continue to be investigated. In order to provide a more thorough evaluation and comparison of treatment plans, the utilization of the biologically effective uniform dose (D) together with the complication-free tumor control probability (P(+)) are examined. Materials and methods:In this study, a typical case of lung cancer was investigated by developing a 3D conformal treatment plan, a linac MLC-based step-and-shoot IMRT plan and a HT plan. The 3 different treatment plans were compared based on radiobiological measures by using the P(+) index and the D concept as the common prescription point of the plans and plotting the tissue response probabilities vs. D for a range of prescription doses. Results: The applied plan evaluation method showed that in this lung cancer case the MLC-based IMRT plan was best over the clinically useful dose prescription range. The 3D-conformal, MLC-based IMRT and HT treatment plans gave a P(+) of 55.4%, 72.9% and 66.9%, for a D to the internal target volume (ITV) of 57.0 Gy, 66.9 Gy and 64.0 Gy, respectively. Conclusion: In comparison to 3D conformal radiotherapy, both Affi based-IMRT and HT can better encompass the often large ITV required while minimizing the volume of the organs at risk receiving high dose. Taking into account the dose-response relations of the irradiated tumors and normal tissues, a radiobiological treatment plan evaluation can be performed, which may provide a closer association of the delivered treatment with the clinical outcome.
引用
收藏
页码:75 / 86
页数:12
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