A novel xanthene-based fluorescence turn-on probe for highly selective detection of Hg2+ in water samples and living cells

被引：15

作者：

Gao, Zhigang ^{[1
]}

Qiu, Siyan ^{[2
]}

Yan, Minchuan ^{[1
]}

Liu, Haibo ^{[1
]}

Lu, Shaohui ^{[1
]}

Lian, Huihui ^{[1
]}

Zhang, Peng ^{[2
]}

Zhu, Jing ^{[2
]}

Jin, Mingjie ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, 200 Xiaolingwei, Nanjing 210094, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Pharm, 138 Xialin Dadao, Nanjing 210023, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1254卷

关键词：

Mercury ion; Fluorescence probe; Xanthene; Real water samples; Cell imaging; INORGANIC MERCURY; AQUEOUS-MEDIA; ION; TRANSPORT; TOXICITY; STRATEGY;

D O I：

10.1016/j.molstruc.2021.132312

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Mercury ions are highly toxic to living organisms and environment, hence Monitoring and quantification of mercury ions remain great significance. Herein, we have designed and synthesized a novel reaction-based fluorescence probe RANS for detection of Hg2+ by using a xanthene derivate as fluorophore and a thiosemicarbazide moiety as the recognition site. By applying mercury-promoted desulfurization reactions, probe RANS exhibited excellent capability of detecting Hg2+, such as rapid response (120 s), high sensitivity (0.019 mu M) and good selectivity. Upon reaction with Hg2+, the thiosemicarbazide group of probe RANS formed 1,3,4-oxadiazole along with a significant color change from colorless to light green. Importantly, RANS has been successfully applied to selectively imaging Hg2+ in living cells with low cytotoxicity and quantitative detection of Hg2+ in real water samples. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：7

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