Dose-Dependent Antimicrobial Activity of Silver Nanoparticles on Polycaprolactone Fibers against Gram-Positive and Gram-Negative Bacteria

被引:139
作者
Pazos-Ortiz, Erick [1 ]
Hafid Roque-Ruiz, Jose [1 ]
Amador Hinojos-Marquez, Efren [1 ]
Lopez-Esparza, Juan [1 ]
Donohue-Cornejo, Alejandro [1 ]
Carlos Cuevas-Gonzalez, Juan [1 ]
Francisco Espinosa-Cristobal, Leon [1 ]
Yobanny Reyes-Lopez, Simon [1 ]
机构
[1] Univ Autonoma Ciudad Juarez, Inst Ciencias Biomed, Envolvente PRONAF & Estocolmo S-N, Ciudad Juarez 32300, Chih, Mexico
关键词
NANOFIBERS;
D O I
10.1155/2017/4752314
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The adhesion ability and adaptability of bacteria, coupled with constant use of the same bactericides, have made the increase in the diversity of treatments against infections necessary. Nanotechnology has played an important role in the search for new ways to prevent and treat infections, including the use of metallic nanoparticles with antibacterial properties. In this study, we worked on the design of a composite of silver nanoparticles (AgNPS) embedded in poly-epsilon-caprolactone nanofibers and evaluated its antimicrobial properties against various Gram-positive and Gram-negative microorganisms associated with drug-resistant infections. Polycaprolactone-silver composites (PCL-AgNPs) were prepared in two steps. The first step consisted in the reduction in situ of Ag+ ions using N, N-dimethylformamide (DMF) in tetrahydrofuran (THF) solution, and the second step involved the simple addition of polycaprolactone before electrospinning process. Antibacterial activity of PCL-AgNPs nanofibers against E. coli, S. mutans, K. pneumoniae, S. aureus, P. aeruginosa, and B. subtilis was evaluated. Results showed sensibility of E. coli, K. pneumoniae, S. aureus, and P. aeruginosa, but not for B. subtilis and S. mutans. This antimicrobial activity of PCL-AgNPs showed significant positive correlations associated with the dose-dependent effect. The antibacterial property of the PCL/Ag nanofibers might have high potential medical applications in drug-resistant infections.
引用
收藏
页数:9
相关论文
共 18 条
[1]   Bacillus subtilis spreads by surfing on waves of surfactant [J].
Angelini, Thomas E. ;
Roper, Marcus ;
Kolter, Roberto ;
Weitz, David A. ;
Brenner, Michael P. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (43) :18109-18113
[2]   Emergence of antibiotic-resistant Pseudomonas aeruginosa:: Comparison of risks associated with different antipseudomonal agents [J].
Carmeli, Y ;
Troillet, N ;
Eliopoulos, GM ;
Samore, MH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1379-1382
[3]   Dual functional core-sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion [J].
Chen, Chih-Hao ;
Chen, Shih-Hsien ;
Shalumon, K. T. ;
Chen, Jyh-Ping .
ACTA BIOMATERIALIA, 2015, 26 :225-235
[4]   Synthesis and Antimicrobial Activity of Silver-Doped Hydroxyapatite Nanoparticles [J].
Ciobanu, Carmen Steluta ;
Iconaru, Simona Liliana ;
Chifiriuc, Mariana Carmen ;
Costescu, Adrian ;
Le Coustumer, Philippe ;
Predoi, Daniela .
BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[5]   Antibacterial effect of silver nanoparticles against Streptococcus mutans [J].
Espinosa-Cristobal, L. F. ;
Martinez-Castanon, G. A. ;
Martinez-Martinez, R. E. ;
Loyola-Rodriguez, J. P. ;
Patino-Marin, N. ;
Reyes-Macias, J. F. ;
Ruiz, Facundo .
MATERIALS LETTERS, 2009, 63 (29) :2603-2606
[6]  
Fernández Riverón Fernando, 2003, Rev Cub Med Mil, V32, P0
[7]   Bovine Serum Albumin and Chitosan Coated Silver Nanoparticles and Its Antimicrobial Activity against Oral and Nonoral Bacteria [J].
Francisco Espinosa-Cristobal, Leon ;
Alejandro Martinez-Castanon, Gabriel ;
Pablo Loyola-Rodriguez, Juan ;
Nino-Martinez, Nereyda ;
Ruiz, Facundo ;
Veronica Zavala-Alonso, Norma ;
Lara, Rene H. ;
Yobanny Reyes-Lopez, Simon .
JOURNAL OF NANOMATERIALS, 2015, 2015
[8]   Preparation of PCL/Clay and PVA/Clay Electrospun Fibers for Cadmium (Cd+2), Chromium (Cr+3), Copper (Cu+2) and Lead (Pb+2) Removal from Water [J].
Hafid Roque-Ruiz, Jose ;
Alexander Cabrera-Ontiveros, Erick ;
Torres-Perez, Jonatan ;
Yobanny Reyes-Lopez, Simon .
WATER AIR AND SOIL POLLUTION, 2016, 227 (08)
[9]   Antimicrobial Activity of Silver Nanoparticles in Polycaprolactone Nanofibers against Gram-Positive and Gram-Negative Bacteria [J].
Lopez-Esparza, Juan ;
Francisco Espinosa-Cristobal, Leon ;
Donohue-Cornejo, Alejandro ;
Yobanny Reyes-Lopez, Simon .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2016, 55 (49) :12532-12538
[10]  
Mensa J, 2008, REV ESP QUIM, V21, P234