Shape-Switching Microrobots for Medical Applications: The Influence of Shape in Drug Delivery and Locomotion

被引：135

作者：

Fusco, Stefano ^{[1
]}

Huang, Hen-Wei ^{[1
]}

Peyer, Kathrin E. ^{[1
,6
]}

Peters, Christian ^{[2
]}

Haeberli, Moritz ^{[1
]}

Ulbers, Andre ^{[1
]}

Spyrogianni, Anastasia ^{[3
]}

Pellicer, Eva ^{[4
]}

Sort, Jordi ^{[4
,5
]}

Pratsinis, Sotiris E. ^{[3
]}

Nelson, Bradley J. ^{[1
]}

Sakar, Mahmut Selman ^{[1
]}

Pane, Salvador ^{[1
]}

机构：

[1] ETH, Inst Robot & Intelligent Syst, CH-8092 Zurich, Switzerland

[2] ETH, Micro & Nanosyst Grp, CH-8092 Zurich, Switzerland

[3] ETH, Particle Technol Lab, CH-8092 Zurich, Switzerland

[4] Univ Autonoma Barcelona, Dept Fis, E-08193 Bellaterra, Spain

[5] Univ Autonoma Barcelona, ICREA, E-08193 Bellaterra, Spain

[6] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 12期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

hydrogel nano composites; self-folding bilayers; drug delivery; magnetic manipulation; microrobotics; HYDROGEL NANOCOMPOSITES; RELEASE BEHAVIORS; NANOPARTICLES; ENCAPSULATION; PARTICLES; TRANSPORT; DESIGN; MICRO; SIZE; FLOW;

D O I：

10.1021/acsami.5b00181

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.

引用

页码：6803 / 6811

页数：9

共 54 条

[11] Intravascular Delivery of Particulate Systems: Does Geometry Really Matter? [J].

Decuzzi, Paolo ;

Pasqualini, Renata ;

Arap, Wadih ;

Ferrari, Mauro .

PHARMACEUTICAL RESEARCH, 2009, 26 (01) :235-243

[12] Synthesis, characterization, and drug release behaviors of a novel thermo-sensitive poly(N-acryloylglycinates) [J].

Deng, Kuilin ;

Zhong, Haibin ;

Zheng, Xiangyang ;

Song, Xiaohui ;

Tian, Hua ;

Zhang, Pengfei ;

Ren, Xiaobo ;

Wang, Haijun .

POLYMERS FOR ADVANCED TECHNOLOGIES, 2010, 21 (08) :584-590

[13] THE USE OF THERMORESPONSIVE HYDROGELS FOR ON-OFF RELEASE OF MOLECULES [J].

DINARVAND, R ;

DEMANUELE, A .

JOURNAL OF CONTROLLED RELEASE, 1995, 36 (03) :221-227

[14] Flow and adhesion of drug carriers in blood vessels depend on their shape: A study using model synthetic microvascular networks [J].

Doshi, Nishit ;

Prabhakarpandian, Balabhaskar ;

Rea-Ramsey, Angela ;

Pant, Kapil ;

Sundaram, Shivshankar ;

Mitragotri, Samir .

JOURNAL OF CONTROLLED RELEASE, 2010, 146 (02) :196-200

[15] Self-folding polymeric containers for encapsulation and delivery of drugs [J].

Fernandes, Rohan ;

Gracias, David H. .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (14) :1579-1589

[16] An Integrated Microrobotic Platform for On-Demand, Targeted Therapeutic Interventions [J].

Fusco, Stefano ;

Sakar, Mahmut Selman ;

Kennedy, Stephen ;

Peters, Christian ;

Bottani, Rocco ;

Starsich, Fabian ;

Mao, Angelo ;

Sotiriou, Georgios A. ;

Pane, Salvador ;

Pratsinis, Sotiris E. ;

Mooney, David ;

Nelson, Bradley J. .

ADVANCED MATERIALS, 2014, 26 (06) :952-957

[17] Shape effects of filaments versus spherical particles in flow and drug delivery [J].

Geng, Yan ;

Dalhaimer, Paul ;

Cai, Shenshen ;

Tsai, Richard ;

Tewari, Manorama ;

Minko, Tamara ;

Discher, Dennis E. .

NATURE NANOTECHNOLOGY, 2007, 2 (04) :249-255

[18] The effect of particle design on cellular internalization pathways [J].

Gratton, Stephanie E. A. ;

Ropp, Patricia A. ;

Pohlhaus, Patrick D. ;

Luft, J. Christopher ;

Madden, Victoria J. ;

Napier, Mary E. ;

DeSimone, Joseph M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (33) :11613-11618

[19] Biopsy with Thermally-Responsive Untethered Microtools [J].

Gultepe, Evin ;

Randhawa, Jatinder S. ;

Kadam, Sachin ;

Yamanaka, Sumitaka ;

Selaru, Florin M. ;

Shin, Eun J. ;

Kalloo, Anthony N. ;

Gracias, David H. .

ADVANCED MATERIALS, 2013, 25 (04) :514-519

[20]

Happel J., 1983, LOW REYNOLDS NUMBER, V1

← 1 2 3 4 5 6 →