Cellulose 3,5-dimethylphenylcarbamate immobilized on silica - A new chiral stationary phase for the analysis of enantiomers

被引：115
作者：
Zhang, T
Nguyen, D
Franco, P
Murakami, T
Ohnishi, A
Kurosawa, H
机构：
[1] Chiral Technol Europe, F-67404 Illkirch Graffenstaden, France
[2] Daicel Chem Ind Ltd, Tsukuba Res Ctr, Tsukuba, Ibaraki 3050841, Japan
来源：
ANALYTICA CHIMICA ACTA | 2006年 / 557卷 / 1-2期
关键词：
enantiomeric separation; chiral stationary phase; immobilization; 3,5-dimethylphenylcarbamate of cellulose; analytical application; HPLC;
D O I：
10.1016/j.aca.2005.10.017
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Recently, we have reported the solvent versatility and enantiomeric resolution performance of an immobilized amylose derivative-based chiral stationary phase (CSP), CHIRALPAK (R) IA. The second member in the same series of immobilized CSPs is CHIRALPAK (R) IB. This new CSP is prepared by immobilizing the chiral selector (the 3,5-dimethylphenylcarbamate derivative of cellulose) onto a 5 mu m spherical porous silica. The aim of this work is to obtain an insight into the chromatographic performance in enantiomeric separation of this new CSP. In addition, we will explore and exploit its enantioselective ability with "non-standard" solvents in the mobile phase. Fundamental information regarding the selection of mobile phases and additives for efficient method development is presented. The CSP stability under "non-standard" mobile phase conditions is demonstrated. (c) 2005 Elsevier B.V. All rights reserved.
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页码：221 / 228
页数：8
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