Extracellular vesicle-mediated bone metabolism in the bone microenvironment

被引：43
作者：
Li, Qi [1 ]
Huang, Qiu-Ping [1 ]
Wang, Yi-Lin [1 ]
Huang, Qing-Sheng [1 ]
机构：
[1] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Space Biotechnol, 127 YouyiXilu, Xian 710072, Shaanxi, Peoples R China
来源：
JOURNAL OF BONE AND MINERAL METABOLISM | 2018年 / 36卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicles; Exosomes; Osteoblasts; Osteoclasts; Bone metastasis; MESENCHYMAL STEM-CELLS; OSTEOGENIC DIFFERENTIATION; MATRIX VESICLES; PROTEOMIC ANALYSIS; MEMBRANE-VESICLES; KEY REGULATOR; TISSUE-REPAIR; EXOSOMES; MICRORNAS; MARROW;
D O I：
10.1007/s00774-017-0860-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Extracellular vesicles (EVs) are phospholipid membrane-enclosed entities containing specific proteins, RNA, miRNA, and lncRNA. EVs are released by various cells and play a vital role in cell communication by transferring their contents from the host cells to the recipient cells. The role of EVs has been characterized in a wide range of physiological and pathophysiological processes. In this context, we highlight recent advances in our understanding of the regulatory effects of EVs, with a focus on bone metabolism and the bone microenvironment. The roles of EVs in cell communication among bone-related cells, stem cells, tumor cells, and other cells under physiological or pathological conditions are also discussed. In addition, promising applications for EVs in treating bone-related diseases are proposed.
引用
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页码：1 / 11
页数：11
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