Chemoselective reductive alkynylation of tertiary amides by Ir and Cu(I) bis-metal sequential catalysis

被引：105

作者：

Huang, Pei-Qiang ^{[1
,2
,3
]}

Ou, Wei ^{[1
,2
]}

Han, Feng ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, iChEM Collaborat Innovat Ctr Chem Energy Mat, Dept Chem, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, iChEM Collaborat Innovat Ctr Chem Energy Mat, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 80期

基金：

中国国家自然科学基金;

关键词：

HIGHLY ENANTIOSELECTIVE CONSTRUCTION; C-H ACTIVATION; SECONDARY AMIDES; NUCLEOPHILIC-ADDITION; GRIGNARD-REAGENTS; TERMINAL ALKYNES; ORGANOMETALLIC REAGENTS; DIRECT TRANSFORMATION; LITHIUM ACETYLIDES; MAGNESIUM REAGENTS;

D O I：

10.1039/c6cc05318a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein a convenient and versatile method for the direct reductive alkynylation of tertiary amides to give propargylic amines through sequential Ir-catalysed hydrosilylation-Cu(I)-catalysed alkynylation. The reactions proceed chemoselectively at the amide group in the presence of several sensitive functional groups including the very reactive aldehyde group on either the amide or the alkyne coupling partner. The method is general for tert-amides with or without alpha-hydrogen.

引用

页码：11967 / 11970

页数：4

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