Asymptomatic Brugada Syndrome case unmasked during dimenhydrinate infusion

被引：41

作者：

Pastor, A ^{[1
]}

Núñez, A ^{[1
]}

Cantale, C ^{[1
]}

Cosío, FG ^{[1
]}

机构：

[1] Hosp Univ Getafe, Serv Cardiol, Clin Electrophysiol Lab, Madrid 28905, Spain

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 2001年 / 12卷 / 10期

关键词：

Brugada syndrome; antihistamine; dimenhydrinate;

D O I：

10.1046/j.1540-8167.2001.01192.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asymptomatic Brugada Syndrome. Typical ECG of that described for Brugada syndrome was elicited in a patient diagnosed with labyrinthopathy during infusion of dimenhydrinate, a first-generation antihistamine usually used to treat motion sickness. Although the patient had no history of syncope or palpitations, and there was no family history of cardiac disease or sudden death, the ECG abnormality was reproduced later with intravenous flecainide, and an asymptomatic Brugada syndrome was diagnosed.

引用

页码：1192 / 1194

页数：3

共 20 条

[1] Brugada syndrome - Clinical data and suggested pathophysiological mechanism [J].

Alings, M ;

Wilde, A .

CIRCULATION, 1999, 99 (05) :666-673

[2] Randomized trial of diphenhydramine versus benzyl alcohol with epinephrine as an alternative to lidocaine local anesthesia [J].

Bartfield, JM ;

Jandreau, SW ;

Raccio-Robak, N .

ANNALS OF EMERGENCY MEDICINE, 1998, 32 (06) :650-654

[3]

Brugada J, 1998, CIRCULATION, V97, P457

[4] RIGHT BUNDLE-BRANCH BLOCK, PERSISTENT ST SEGMENT ELEVATION AND SUDDEN CARDIAC DEATH - A DISTINCT CLINICAL AND ELECTROCARDIOGRAPHIC SYNDROME - A MULTICENTER REPORT [J].

BRUGADA, P ;

BRUGADA, J .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 20 (06) :1391-1396

[5] Sodium channel blockers identify risk for sudden death in patients with ST-Segment elevation and right bundle branch block but structurally normal hearts [J].

Brugada, R ;

Brugada, J ;

Antzelevitch, C ;

Kirsch, GE ;

Potenza, D ;

Towbin, JA ;

Brugada, P .

CIRCULATION, 2000, 101 (05) :510-515

[6] Genetic basis and molecular mechanism for idiopathic: ventricular fibrillation [J].

Chen, QY ;

Kirsch, GE ;

Zhang, DM ;

Brugada, R ;

Brugada, J ;

Brugada, P ;

Potenza, D ;

Moya, A ;

Borggrefe, M ;

Breithardt, G ;

Ortiz-Lopez, R ;

Wang, Z ;

Antzelevitch, C ;

O'Brien, RE ;

Schulze-Bahr, E ;

Keating, MT ;

Towbin, JA ;

Wang, Q .

NATURE, 1998, 392 (6673) :293-296

[7] RESPONSE OF LIFE THREATENING DIMENHYDRINATE INTOXICATION TO SODIUM-BICARBONATE ADMINISTRATION [J].

FARRELL, M ;

HEINRICHS, M ;

TILELLI, JA .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1991, 29 (04) :527-535

[8] ANTIARRHYTHMIC ACTIONS OF ANTIHISTAMINES [J].

GIOTTI, A ;

ZILLETTI, L .

PHARMACOLOGY & THERAPEUTICS PART B-GENERAL & SYSTEMATIC PHARMACOLOGY, 1976, 2 (04) :863-900

[9] The Brugada syndrome: Clinical, electrophysiologic and genetic aspects [J].

Gussak, I ;

Antzelevitch, C ;

Bjerregaard, P ;

Towbin, JA ;

Chaitman, BR .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (01) :5-15

[10] Idiopathic ventricular fibrillation induced with vagal activity in patients without obvious heart disease [J].

Kasanuki, H ;

Ohnishi, S ;

Ohtuka, M ;

Matsuda, N ;

Nirei, T ;

Isogai, R ;

Shoda, M ;

Toyoshima, Y ;

Hosoda, S .

CIRCULATION, 1997, 95 (09) :2277-2285

← 1 2 →