Serrated adenoma and colorectal cancer

被引：3

作者：

Jass, JR ^{[1
]}

机构：

[1] Univ Queensland, Mayne Med Sch, Dept Pathol, Herston, Qld 4006, Australia

来源：

JOURNAL OF PATHOLOGY | 1999年 / 187卷 / 05期

关键词：

colorectum; polyp; hyperplastic; adenoma; serrated; mucin; microsatellite instability;

D O I：

10.1002/(SICI)1096-9896(199904)187:5<499::AID-PATH309>3.0.CO;2-B

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) and intestinal (MUC2) mucins, They also share the phenotype of mild DNA microsatellite instability (MSI-L), Recent findings of clonal genetic changes within hyperplastic polyps fit with a pathway of serrated neoplasia, perhaps culminating in the subset of colorectal cancer characterized by the mild mutator phenotype, Copyright (C) 1999 John Wiley & Sons, Ltd.

引用

页码：499 / 502

页数：4

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