Serrated adenoma and colorectal cancer

被引：3
作者：
Jass, JR [1 ]
机构：
[1] Univ Queensland, Mayne Med Sch, Dept Pathol, Herston, Qld 4006, Australia
来源：
JOURNAL OF PATHOLOGY | 1999年 / 187卷 / 05期
关键词：
colorectum; polyp; hyperplastic; adenoma; serrated; mucin; microsatellite instability;
D O I：
10.1002/(SICI)1096-9896(199904)187:5<499::AID-PATH309>3.0.CO;2-B
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) and intestinal (MUC2) mucins, They also share the phenotype of mild DNA microsatellite instability (MSI-L), Recent findings of clonal genetic changes within hyperplastic polyps fit with a pathway of serrated neoplasia, perhaps culminating in the subset of colorectal cancer characterized by the mild mutator phenotype, Copyright (C) 1999 John Wiley & Sons, Ltd.
引用
收藏
页码：499 / 502
页数：4
相关论文
共 29 条
  • [1] Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum
    Ajioka, Y
    Watanabe, H
    Jass, JR
    Yokota, Y
    Kobayashi, M
    Nishikura, K
    [J]. GUT, 1998, 42 (05) : 680 - 684
  • [2] Bara J, 1998, INT J CANCER, V75, P767, DOI 10.1002/(SICI)1097-0215(19980302)75:5<767::AID-IJC17>3.0.CO
  • [3] 2-3
  • [4] BARDI G, 1993, CANCER RES, V53, P1895
  • [5] MONOCLONAL-ANTIBODIES REACTING WITH THE MUC2 MUCIN CORE PROTEIN
    DEVINE, PL
    MCGUCKIN, MA
    BIRRELL, GW
    WHITEHEAD, RH
    SACHDEV, GP
    SHIELD, P
    WARD, BG
    [J]. BRITISH JOURNAL OF CANCER, 1993, 67 (06) : 1182 - 1188
  • [6] Dietmaier W, 1997, CANCER RES, V57, P4749
  • [7] Hiyama T, 1998, J PATHOL, V186, P131
  • [8] DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?
    Iino, H
    Jass, JR
    Simms, LA
    Young, J
    Leggett, B
    Ajioka, Y
    Watanabe, H
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1999, 52 (01) : 5 - 9
  • [9] SIALIC-ACID AND EPITHELIAL DIFFERENTIATION IN COLORECTAL POLYPS AND CANCER - A MORPHOLOGICAL, MUCIN AND LECTIN HISTOCHEMICAL-STUDY
    JASS, JR
    SMITH, M
    [J]. PATHOLOGY, 1992, 24 (04) : 233 - 242
  • [10] Morphology of sporadic colorectal cancer with DNA replication errors
    Jass, JR
    Do, KA
    Simms, LA
    Iino, H
    Wynter, C
    Pillay, SP
    Searle, J
    Radford-Smith, G
    Young, J
    Leggett, B
    [J]. GUT, 1998, 42 (05) : 673 - 679
123