Adjuvant chemotherapy after neoadjuvant chemo-radiotherapy and surgery in locally advanced rectal cancer. A systematic review of literature with a meta-analysis of randomized clinical trials

被引：17

作者：

Tamburini, Emiliano ^{[1
]}

Tassinari, Davide ^{[2
]}

Ramundo, Matteo ^{[1
]}

De Stefano, Alfonso ^{[3
]}

Viola, Massimo Giuseppe ^{[4
]}

Romano, Carmela ^{[3
]}

Elia, Maria Teresa ^{[1
]}

Zanaletti, Nicoletta ^{[3
]}

Rudnas, Britt ^{[5
]}

Casadei-Gardini, Andrea ^{[6
,7
]}

Delrio, Paolo ^{[8
]}

Toma, Ilaria ^{[1
]}

Granata, Vincenza ^{[9
]}

Petrucelli, Luciana ^{[1
]}

Avallone, Antonio ^{[3
]}

机构：

[1] Cardinale G Panico Tricase City Hosp, Dept Oncol & Palliat Care, Tricase, Italy

[2] City Hosp, Dept Oncol, Rimini, Italy

[3] IRCCS Fdn G Pascale, Ist Nazl Tumori, Expt Clin Abdominal Oncol Unit, Naples, Italy

[4] Cardinale G Panico Tricase City Hosp, Dept Surg, Tricase, Italy

[5] IRCCS Ist Romagnolo Studio Tumori IRST, Unit Biostat & Clin Trials, Meldola, Italy

[6] Univ Vita Salute San Raffaele, Sch Med, Milan, Italy

[7] IRCCS San Raffaele Sci Inst, Unit Oncol 3, Milan, Italy

[8] IRCCS Fdn G Pascale, Ist Nazl Tumori, Colorectal Oncol Surg, Naples, Italy

[9] IRCCS Fdn G Pascale, Ist Nazl Tumori, Radiol Unit, Naples, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2022年 / 172卷

关键词：

Rectal cancer; Adjuvant chemotherapy; Fluoropyrimidine; Oxaliplatin; FOLFOX XELOX; TOTAL MESORECTAL EXCISION; III COLON-CANCER; PREOPERATIVE CHEMORADIOTHERAPY; OPEN-LABEL; POSTOPERATIVE CHEMORADIOTHERAPY; FOLLOW-UP; FLUOROURACIL; RADIOTHERAPY; OXALIPLATIN; MULTICENTER;

D O I：

10.1016/j.critrevonc.2022.103627

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Highlights: Although no definitive data exist in literature, adjuvant chemotherapy is usually recommended in patients with radically resected stage III rectal cancer treated with neo-adjuvant chemo-radiotherapy. We performed a systematic review of literature with direct and indirect comparisons to assess the role of adjuvant mono or poli-chemotherapy in radically resected rectal cancer treated with neoadjuvant chemo-radiotherapy. Neither chemotherapy (mono-or poli-chemotherapy) nor polichemotherapy with oxaliplatin-containing regimens seems to improve Overall Survival and Disease-Free Survival in patients with radically resected rectal cancer treated with neoadjuvant chemo-adiotherapy. Neither the entire population of patients radically resected after neoadjuvant chemotherapy, nor high risk patients seem to benefit from adjuvant chemotherapy. Our data seem to suggest the need of review the actual international guidelines that suggest the need of adjuvant chemotherapy at least in high risk rectal cancer treated with surgery and neoadjuvant chemo-radiotherapy.

引用

页数：9

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