Persistence: mechanisms for triggering and enhancing phenotypic variability

被引:111
作者
Balaban, N. Q. [1 ,2 ]
机构
[1] Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel
基金
欧洲研究理事会;
关键词
TOXIN-ANTITOXIN SYSTEMS; ESCHERICHIA-COLI; BACTERIAL PERSISTENCE; BACILLUS-SUBTILIS; SINGLE-CELL; PSEUDOMONAS-AERUGINOSA; GENE-EXPRESSION; STRESS-RESPONSE; ANTIBIOTIC TOLERANCE; MULTIDRUG TOLERANCE;
D O I
10.1016/j.gde.2011.10.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
When microorganisms are exposed to lethal agents, the initial exponential decay in survival is typically followed by a slower decrease. This tailing of the survival curve is due to persister cells that have differentiated into phenotypes with reduced sensitivity to the lethal agent. We review the environmental factors that have been shown to trigger such differentiation processes, as well as the network motifs that enable the coexistence of persistent and nonpersistent cells within genetically uniform populations. Threshold amplification of noise and bi-stability from positive feedback emerge as key motifs underlying persistence.
引用
收藏
页码:768 / 775
页数:8
相关论文
共 72 条
  • [51] Persister cells, dormancy and infectious disease
    Lewis, Kim
    [J]. NATURE REVIEWS MICROBIOLOGY, 2007, 5 (01) : 48 - 56
  • [52] A molecular model for persister in E. coli
    Lou, Chunbo
    Li, Zhengyan
    Qi Ouyang
    [J]. JOURNAL OF THEORETICAL BIOLOGY, 2008, 255 (02) : 205 - 209
  • [53] Age of Inoculum Strongly Influences Persister Frequency and Can Mask Effects of Mutations Implicated in Altered Persistence
    Luidalepp, Hannes
    Joers, Arvi
    Kaldalu, Niilo
    Tenson, Tanel
    [J]. JOURNAL OF BACTERIOLOGY, 2011, 193 (14) : 3598 - 3605
  • [54] RETRACTED: Bacterial persistence by RNA endonucleases (Retracted Article)
    Maisonneuve, Etienne
    Shakespeare, Lana J.
    Jorgensen, Mikkel Girke
    Gerdes, Kenn
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (32) : 13206 - 13211
  • [55] Pseudomonas aeruginosa Increases Formation of Multidrug-Tolerant Persister Cells in Response to Quorum-Sensing Signaling Molecules
    Moeker, Nina
    Dean, Charles R.
    Tao, Jianshi
    [J]. JOURNAL OF BACTERIOLOGY, 2010, 192 (07) : 1946 - 1955
  • [56] HIPA, A NEWLY RECOGNIZED GENE OF ESCHERICHIA-COLI K-12 THAT AFFECTS FREQUENCY OF PERSISTENCE AFTER INHIBITION OF MUREIN SYNTHESIS
    MOYED, HS
    BERTRAND, KP
    [J]. JOURNAL OF BACTERIOLOGY, 1983, 155 (02) : 768 - 775
  • [57] Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis
    Mulcahy, Lawrence R.
    Burns, Jane L.
    Lory, Stephen
    Lewis, Kim
    [J]. JOURNAL OF BACTERIOLOGY, 2010, 192 (23) : 6191 - 6199
  • [58] Multistability in the lactose utilization network of Escherichia coli
    Ozbudak, EM
    Thattai, M
    Lim, HN
    Shraiman, BI
    van Oudenaarden, A
    [J]. NATURE, 2004, 427 (6976) : 737 - 740
  • [59] Nongenetic individuality in the host-phage interaction
    Pearl, Sivan
    Gabay, Chana
    Kishony, Roy
    Oppenheim, Amos
    Balaban, Nathalie Q.
    [J]. PLOS BIOLOGY, 2008, 6 (05) : 957 - 964
  • [60] RAMAGE HR, 2009, PLOS GENET, P5