Atherosclerosis: Known and unknown

被引:281
作者
Fan, Jianglin [1 ,2 ]
Watanabe, Teruo [3 ]
机构
[1] Univ Yamanashi, Fac Med, Interdisciplinary Grad Sch Med Sci, Dept Mol Pathol, 1110 Shimokato, Chuo 4093898, Japan
[2] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China
[3] Fukuoka Wajiro Hosp, Div Lab Med & Pathol, Fukuoka, Japan
基金
中国国家自然科学基金; 日本学术振兴会;
关键词
animal models; atherosclerosis; hypercholesterolemia; pathology; HISTOLOGICAL CLASSIFICATION; VASCULAR-LESIONS; PLAQUE RUPTURE; FATTY STREAK; YOUNG-ADULTS; EXPRESSION; MICE; PATHOGENESIS; MACROPHAGES; LIPOPROTEIN;
D O I
10.1111/pin.13202
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Atherosclerotic disease, such as myocardial infarction and stroke, is the number one killer worldwide. Atherosclerosis is considered to be caused by multiple factors, including genetic and environmental factors. In humans, it takes several decades until the clinical complications develop. There are many known risk factors for atherosclerosis, including hypercholesterolemia, hypertension, diabetes and smoking, which are involved in the pathogenesis of atherosclerosis; however, it is generally believed that atherosclerosis is vascular chronic inflammation initiated by interactions of these risk factors and arterial wall cells. In the past 30 years, the molecular mechanisms underlying the pathogenesis of atherosclerosis have been investigated extensively using genetically modified animals, and lipid-reducing drugs, such as statins, have been demonstrated as the most effective for the prevention and treatment of atherosclerosis. However, despite this progress, questions regarding the pathogenesis of atherosclerosis remain and there is a need to develop new animal models and novel therapeutics to treat patients who cannot be effectively treated by statins. In this review, we will focus on two topics of atherosclerosis, "pathology" and "pathogenesis," and discuss unanswered questions.
引用
收藏
页码:151 / 160
页数:10
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