Effectiveness and safety of anti-TNF in psoriatic arthritis patients in Brazil: a post-incorporation analysis

被引：9
作者：
Ribeiro da Silva, Michael Ruberson [1 ]
Ribeiro dos Santos, Jessica Barreto [1 ]
Almeida, Alessandra Maciel [2 ]
Kakehasi, Adriana Maria [3 ]
de Oliveira Junior, Haliton Alves [1 ]
Alvares-Teodoro, Juliana [2 ]
Acurcio, Francisco de Assis [2 ,3 ]
机构：
[1] Univ Fed Minas Gerais, Coll Pharm, Postgrad Program Med & Pharmaceut Assistance, President Antonio Carlos Ave,6627,Campus Pampulha, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Coll Pharm, President Antonio Carlos Ave,6627,Campus Pampulha, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Med Sch, Prof Alfredo Balena Ave 190, BR-30130100 Belo Horizonte, MG, Brazil
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2018年 / 7卷 / 10期
关键词：
anti-TNF-alpha; Brazil; cohort study; effectiveness; psoriatic arthritis; safety; DRUG SURVIVAL; PHARMACOLOGICAL-TREATMENT; EULAR RECOMMENDATIONS; RHEUMATOID-ARTHRITIS; TREATMENT RESPONSE; ETANERCEPT; MANAGEMENT; THERAPIES; EFFICACY; DISEASE;
D O I：
10.2217/cer-2018-0017
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Aim: Psoriatic arthritis is a chronic disease that can result in disability and decreased quality of life. Materials & methods: A prospective cohort was conducted in Brazil. Disease activity was measured by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Clinical Disease Activity Index (CDAI), functionality by the Health Assessment Questionnaire Disability Index (HAQ-DI) and the quality of life by the EuroQol 5D (EQ-5D). Results: In total, 122 patients were included. After 6 months, a median reduction of 2.03 in the BASDAI, 7.80 in the CDAI, 0.63 in the HAQ-DI and increase of 0.12 in the EQ-5D was observed. A good clinical response was observed in 45.5% of the patients by BASDAI and 54.5% by CDAI. Higher education and better quality of life were identified as predictors of effectiveness. The most common side effects were the infections. Conclusion: Anti-TNF-alpha drugs were effective and safe. The incorporation of them into the Brazilian Public Health System has provided therapeutic alternatives to the treatment of psoriatic arthritis.
引用
收藏
页码：989 / 1000
页数：12
相关论文
共 42 条
[1]   Effectiveness and drug survival of TNF-inhibitors in the treatment of psoriatic arthritis: A prospective cohort study [J].
Aaltonen, Kalle ;
Heinonen, Arto ;
Joensuu, Jaana ;
Parmanne, Pinja ;
Karjalainen, Anna ;
Varjolahti-Lehtinen, Tuire ;
Uutela, Toini ;
Puurtinen-Vilkki, Maija ;
Arstila, Leena ;
Blom, Marja ;
Sokka, Tuulikki ;
Nordstrom, Dan .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2017, 46 (06) :732-739
[2]   World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects [J].
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (20) :2191-2194
[3]   Evaluation of fatigue and its correlation with quality of life index, anxiety symptoms, depression and activity of disease in patients with psoriatic arthritis [J].
Carneiro, Claudio ;
Chaves, Mario ;
Verardino, Gustavo ;
Frade, Ana Paula ;
Coscarelli, Pedro Guimaraes ;
Bianchi, Washington Alves ;
Ramos-e-Silva, Marcia ;
Carneiro, Sueli .
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2017, 10 :155-163
[4]   Recommendations for the management and treatment of psoriatic arthritis [J].
Carneiro, Sueli ;
Azevedo, Valderilio Feijo ;
Bonfiglioli, Rubens ;
Ranza, Roberto ;
Goncalves, Celio Roberto ;
Keiserman, Mauro ;
Meirelles, Eduardo de Souza ;
Pinheiro, Marcelo de Medeiros ;
Ximenes, Antonio Carlos ;
Bernardo, Wanderley ;
Sampaio-Barros, Percival Degrava .
REVISTA BRASILEIRA DE REUMATOLOGIA, 2013, 53 (03) :227-241
[5]   Systematic review, network meta-analysis and economic evaluation of biological therapy for the management of active psoriatic arthritis [J].
Cawson, Matthew Richard ;
Mitchell, Stephen Andrew ;
Knight, Chris ;
Wildey, Henry ;
Spurden, Dean ;
Bird, Alex ;
Orme, Michelle Elaine .
BMC MUSCULOSKELETAL DISORDERS, 2014, 15
[6]   Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis [J].
Coates, Laura C. ;
Kavanaugh, Arthur ;
Mease, Philip J. ;
Soriano, Enrique R. ;
Acosta-Felquer, Maria Laura ;
Armstrong, April W. ;
Bautista-Molano, Wilson ;
Bochncke, Wolf -Henning ;
Campbc, Willemina ;
Cauli, Alberto ;
Espinoza, Luis R. ;
FitzGerald, Oliver ;
Gladman, Dafna D. ;
Gottlieb, Alice ;
Helliwel, Philip S. ;
Husni, M. Elaine ;
Love, Thorvardur J. ;
Lubrano, Ennio ;
McHugh, Neil ;
Nash, Peter ;
Ogdie, Alexis ;
Orbai, Ana -Maria ;
Parkinson, Andrew ;
O'Sullivan, Denis ;
Rosen, Cheryl F. ;
Schwartzman, Sergio ;
Siege, Evan L. ;
Toloza, Sergio ;
Tuong, William ;
Ritchlin, Christopher T. .
ARTHRITIS & RHEUMATOLOGY, 2016, 68 (05) :1060-1071
[7]   Is ASDAS better than BASDAI as a measure of disease activity in axial psoriatic arthritis? [J].
Eder, Lihi ;
Chandran, Vinod ;
Shen, Hua ;
Cook, Richard J. ;
Gladman, Dafna D. .
ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (12) :2160-2164
[8]   Direct and indirect comparison of the efficacy and safety of adalimumab, etanercept, infliximab and golimumab in psoriatic arthritis [J].
Fenix-Caballero, S. ;
Alegre-del Rey, E. J. ;
Castano-Lara, R. ;
Puigventos-Latorre, F. ;
Borrero-Rubio, J. M. ;
Lopez-Vallejo, J. F. .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2013, 38 (04) :286-293
[9]  
Garcia-Doval I, 2012, ARCH DERMATOL, V148, P463, DOI 10.1001/archdermatol.2011.2768
[10]   Normality Tests for Statistical Analysis: A Guide for Non-Statisticians [J].
Ghasemi, Asghar ;
Zahediasl, Saleh .
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2012, 10 (02) :486-489
12345