Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial of a Novel Nutritional Supplement Product to Promote Healthy Skin

被引:0
作者
Dayan, Steven H. [1 ]
Arkins, John P.
Sharma, Vinny [2 ]
Paterson, Elaine
Barnes, David
机构
[1] Univ Illinois, Chicago Ctr Facial Plast Surg, Chicago, IL 60611 USA
[2] Lake Erie Coll Osteopath Med, Bradenton, FL USA
关键词
CLOSED UNVENTILATED CHAMBER; TRANSEPIDERMAL WATER-LOSS; VITAMIN-E CONSUMPTION; CORONARY-DISEASE; STRATUM-CORNEUM; ANTIOXIDANTS; CAROTENOIDS; PREVENTION; RADIATION; EFFICACY;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Despite an abundance of nutritional supplements, very few well-controlled trials have assessed their beneficial effect on the skin, such as hydration, antioxidant levels, texture or appearance. The objective of the following placebo-controlled, double-blind study was to determine the effects of the Skin Health Experimental Product (SHEP) on skin health. Methods: The study enrolled healthy men and women aged 30 years or older. Subjects were randomized to receive a twice-daily regimen of SHEP or placebo. The effects SHEP had on overall skin appearance and health were assessed by measuring improvements in: (1) skin hydration using a closed-aperture transepidermal water-loss moisture meter and a vapometer; (2) skin texture using silicon profilometry; (3) skin carotenoid concentration using Raman spectrometry; and (4) reported self-image assessments using the Global Aesthetic Improvement Scale (GAIS). Results: SHEP-treated subjects demonstrated a significant reduction in fine lines compared to the placebo-treated group. Raman spectroscopy showed that SHEP increased carotenoids at some measurement sites. Based on the GAIS, SHEP-treated subjects were three times more likely to perceive an improvement in their appearance compared to placebo-treated subjects (P>0.049). Conclusion: The orally-administered SHEP nutritional supplement improves skin texture, carotenoid levels in specific areas of the hand, and improves patients' perception of skin health.
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页码:1106 / 1114
页数:9
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