Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

被引：176
作者：
Tuon, Felipe Francisco [1 ]
Dantas, Leticia Ramos [1 ]
Suss, Paula Hansen [1 ]
Tasca Ribeiro, Victoria Stadler [1 ]
机构：
[1] Pontificia Univ Catolica Parana, Sch Med, Lab Emerging Infect Dis, BR-80215901 Curitiba, Parana, Brazil
来源：
PATHOGENS | 2022年 / 11卷 / 03期
关键词：
Pseudomonas aeruginosa; biofilm; quorum sensing; virulence; ACUTE KIDNEY INJURY; AMINOGLYCOSIDE-MODIFYING ENZYMES; HOMOSERINE LACTONE ACYLASE; COATED ENDOTRACHEAL-TUBES; INNATE IMMUNE-RESPONSE; INTENSIVE-CARE-UNIT; CYSTIC-FIBROSIS; RISK-FACTORS; TRANSCRIPTIONAL ACTIVATOR; TWITCHING MOTILITY;
D O I：
10.3390/pathogens11030300
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pseudomonas aeruginosa is associated with several human infections, mainly related to healthcare services. In the hospital, it is associated with resistance to several antibiotics, which poses a great challenge to therapy. However, one of the biggest challenges in treating P. aeruginosa infections is that related to biofilms. The complex structure of the P. aeruginosa biofilm contributes an additional factor to the pathogenicity of this microorganism, leading to therapeutic failure, in addition to escape from the immune system, and generating chronic infections that are difficult to eradicate. In this review, we address several molecular aspects of the pathogenicity of P. aeruginosa biofilms.
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页数：19
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