Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

被引：176
作者：
Tuon, Felipe Francisco [1 ]
Dantas, Leticia Ramos [1 ]
Suss, Paula Hansen [1 ]
Tasca Ribeiro, Victoria Stadler [1 ]
机构：
[1] Pontificia Univ Catolica Parana, Sch Med, Lab Emerging Infect Dis, BR-80215901 Curitiba, Parana, Brazil
来源：
PATHOGENS | 2022年 / 11卷 / 03期
关键词：
Pseudomonas aeruginosa; biofilm; quorum sensing; virulence; ACUTE KIDNEY INJURY; AMINOGLYCOSIDE-MODIFYING ENZYMES; HOMOSERINE LACTONE ACYLASE; COATED ENDOTRACHEAL-TUBES; INNATE IMMUNE-RESPONSE; INTENSIVE-CARE-UNIT; CYSTIC-FIBROSIS; RISK-FACTORS; TRANSCRIPTIONAL ACTIVATOR; TWITCHING MOTILITY;
D O I：
10.3390/pathogens11030300
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pseudomonas aeruginosa is associated with several human infections, mainly related to healthcare services. In the hospital, it is associated with resistance to several antibiotics, which poses a great challenge to therapy. However, one of the biggest challenges in treating P. aeruginosa infections is that related to biofilms. The complex structure of the P. aeruginosa biofilm contributes an additional factor to the pathogenicity of this microorganism, leading to therapeutic failure, in addition to escape from the immune system, and generating chronic infections that are difficult to eradicate. In this review, we address several molecular aspects of the pathogenicity of P. aeruginosa biofilms.
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页数：19
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共 184 条
  • [1] Pathogenic factors of Pseudomonas aeruginosa - the role of biofilm in pathogenicity and as a target for phage therapy
    Al-Wrafy, Fairoz
    Brzozowska, Ewa
    Gorska, Sabina
    Gamian, Andrzej
    [J]. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2017, 71 : 78 - 91
  • [2] Human probiotic bacteria attenuatePseudomonas aeruginosabiofilm and virulence byquorum-sensinginhibition
    Anabel Diaz, Myriam
    Nelina Gonzalez, Silvia
    Rosa Alberto, Maria
    Eduardo Arena, Mario
    [J]. BIOFOULING, 2020, 36 (05) : 597 - 609
  • [3] Targeting the Type Three Secretion System in Pseudomonas aeruginosa
    Anantharajah, Ahalieyah
    Mingeot-Leclercq, Marie-Paule
    Van Bambeke, Francoise
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2016, 37 (09) : 734 - 749
  • [4] Activity of imipenem-relebactam and ceftolozane-tazobactam against carbapenem-resistant Pseudomonas aeruginosa and KPC-producing Enterobacterales
    Bail, Larissa
    Sanches Ito, Carmen Antonia
    Villa Stangler Arend, Lavinia Nery
    Nogueira, Keite da Silva
    Tuon, Felipe Francisco
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2022, 102 (01)
  • [5] Pseudomonas Evades Immune Recognition of Flagellin in Both Mammals and Plants
    Bardoel, Bart W.
    van der Ent, Sjoerd
    Pel, Michiel J. C.
    Tommassen, Jan
    Pieterse, Corne M. J.
    van Kessel, Kok P. M.
    van Strijp, Jos A. G.
    [J]. PLOS PATHOGENS, 2011, 7 (08)
  • [6] Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation by Pseudomonas aeruginosa
    Bedi, Brahmchetna
    Maurice, Nicholas M.
    Ciavatta, Vincent T.
    Lynn, K. Sabrina
    Yuan, Zhihong
    Molina, Samuel A.
    Joo, Myungsoo
    Tyor, William R.
    Goldberg, Joanna B.
    Koval, Michael
    Hart, C. Michael
    Sadikot, Ruxana T.
    [J]. FASEB JOURNAL, 2017, 31 (08) : 3608 - 3621
  • [7] Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma
    Bedi, Brahmchetna
    Yuan, Zhihong
    Joo, Myungsoo
    Zughaier, Susu M.
    Goldberg, Joanna B.
    Arbiser, Jack L.
    Hart, C. Michael
    Sadikot, Ruxana T.
    [J]. INFECTION AND IMMUNITY, 2016, 84 (07) : 1975 - 1985
  • [8] Occurrence of aminoglycoside-modifying enzymes among isolates of Escherichia coli exhibiting high levels of aminoglycoside resistance isolated from Korean cattle farms
    Belaynehe, Kuastros Mekonnen
    Shin, Seung Won
    Hong-Tae, Park
    Yoo, Han Sang
    [J]. FEMS MICROBIOLOGY LETTERS, 2017, 364 (14)
  • [9] A Novel Metagenomic Short-Chain Dehydrogenase/Reductase Attenuates Pseudomonas aeruginosa Biofilm Formation and Virulence on Caenorhabditis elegans
    Bijtenhoorn, Patrick
    Mayerhofer, Hubert
    Mueller-Dieckmann, Jochen
    Utpatel, Christian
    Schipper, Christina
    Hornung, Claudia
    Szesny, Matthias
    Grond, Stephanie
    Thuermer, Andrea
    Brzuszkiewicz, Elzbieta
    Daniel, Rolf
    Dierking, Katja
    Schulenburg, Hinrich
    Streit, Wolfgang R.
    [J]. PLOS ONE, 2011, 6 (10):
  • [10] Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
    Bjarnsholt, T
    Jensen, PO
    Rasmussen, TB
    Christophersen, L
    Calum, H
    Hentzer, M
    Hougen, HP
    Rygaard, J
    Moser, C
    Eberl, L
    Hoiby, N
    Givskov, M
    [J]. MICROBIOLOGY-SGM, 2005, 151 : 3873 - 3880
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