RAS And PKA pathways in cancer: new insight from transcriptional analysis

被引：31

作者：

Chiaradonna, Ferdinando ^{[1
]}

Balestrieri, Chiara ^{[1
]}

Gaglio, Daniela ^{[1
]}

Vanoni, Marco ^{[1
]}

机构：

[1] Univ Milan, Dept Biosci & Biotechnol, I-20126 Milan, Italy

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

Ras; oncogene; cAMP; PKA; transcriptional; regulation; transformation; cancer; review;

D O I：

10.2741/3079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Through its ability to regulate the activity of a large number of transcription factors, the Ras pathway is able to control several transcriptional programs leading to proliferation, differentiation, metabolism, cytoskeletal reorganization and immune response. Cyclic AMP ( cAMP) is a ubiquitous intracellular second messenger whose major intracellular target in eukaryotes is protein kinase A (PKA). Wide evidence for cross talk between the Ras and cAMP-PKA pathways is available. After reviewing some features of Ras and PKA signalling that are relevant for cancer biology, we re-analyze available genome-wide expression data for genes encoding proteins of the downstream branch of the PKA pathway in human tumor cell lines as a function of the mutational state of the Ras pathway. The observed Ras-dependent pattern of regulation of the analyzed genes may contribute to explain how the cAMP-PKA axis is involved in oncogenic processes induced by Ras.

引用

页码：5257 / 5278

页数：22

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