Glionitrin B, a Cancer Invasion Inhibitory Diketopiperazine Produced by Microbial Coculture

被引：54

作者：

Park, Hyun Bong ^{[1
,2
]}

Kim, Young-Joo ^{[2
]}

Park, Jin-Soo ^{[2
]}

Yang, Hyun Ok ^{[2
]}

Lee, Kang Ro ^{[1
]}

Kwon, Hak Cheol ^{[2
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 440746, South Korea

[2] Korea Inst Sci & Technol, Nat Med Ctr, Kangnung, Gangwondo, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

ASPERGILLUS-FUMIGATUS; GENE-CLUSTER; BIOSYNTHESIS; FUNGUS; BISDETHIOBIS(METHYLTHIO)GLIOTOXIN; IDENTIFICATION; FERMENTATION; ANTAGONISTS; METABOLITE; SCAFFOLD;

D O I：

10.1021/np200563x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new diketopiperazine, glionitrin B (1), was produced using a microbial coculture of the fungus Aspergillus fumigatus KMC-901 and the bacterium Sphingomonas sp. KMK-001 that were isolated from acidic coal mine drainage. The structure of 1 was determined to be (3S,10aS)-dithiomethylglionitrin A. This structure was determined by the analyses of extensive NMR data and the circular dichroism spectra of the natural product and a semisynthetic compound derived from glionitrin A. In contrast to glionitrin A (2), glionitrin B (1) is not cytotoxic against the human prostate cancer cell line DU145. However, compound 1 caused suppression of DU145 cell invasion, producing 46% inhibition at 60 mu M.

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页码：2309 / 2312

页数：4

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