Disease reactivation after fingolimod cessation in Multiple Sclerosis patients with pregnancy desire: A retrospective study

被引：7

作者：

Callens, Alix ^{[1
]}

Leblanc, Soline ^{[2
]}

Le Page, Emmanuelle ^{[1
]}

Edan, Gilles ^{[1
]}

Jourdain, Aurore ^{[3
]}

Coustans, Marc ^{[4
]}

Wiertlewski, Sandrine ^{[5
,6
]}

Laplaud, David ^{[5
,6
,7
]}

Videth, Dorothee ^{[8
]}

Lallement, Francois ^{[9
]}

Leray, Emmanuelle ^{[2
]}

Michel, Laure ^{[1
]}

机构：

[1] Rennes Univ, Rennes Univ Hosp, CHU Pontchaillou,Rennes Clin Invest Ctr CIC P 141, Neurol Dept,Serv Neurol,CRCSEP,INSERM, F-35033 Rennes, France

[2] Univ Rennes, EHESP, CNRS, INSERM,ARENES,UMR 6051,RSMS U1309, Rennes, France

[3] Brest Hosp & Univ, Neurol Dept, Brest, France

[4] CHIC Quimper Hosp, Neurol Dept, Quimper, France

[5] INSERM, CIC 1413, F-44000 Nantes, France

[6] CHU Nantes, Serv Neurol, Nantes, France

[7] Nantes Univ, INSERM, Ctr Res Transplantat & Translat Immunol, UMR 1064, F-44000 Nantes, France

[8] Vannes Hosp, Neurol Dept, Vannes, France

[9] St Brieuc Hosp, Dept Neurol, St Brieuc, France

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2022年 / 66卷

关键词：

Multiple Sclerosis; Fingolimod-disease reactivation; Pregnancy desire;

D O I：

10.1016/j.msard.2022.104066

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Reactivation of Multiple Sclerosis (MS) activity has been described after fingolimod cessation. Because of its contra indication during pregnancy, switch towards lower efficacy treatments are frequent in MS patients with childbearing desire but expose them to a risk of disease reactivation. In this retrospective study including 44 women with MS, a significant increase of the median annualized relapse rate was found in the year following fingolimod discontinuation compared to the period before (p < 0.0001), and 57% of women experienced at least one relapse. When considering to start fingolimod, particular attention should be paid to women with a short-term pregnancy desire.

引用

页数：3

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