Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice

被引：27

作者：

Kang, Myung-Soo ^{[2
]}

Soni, Vishal ^{[2
]}

Bronson, Roderick

Kieff, Elliott ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Channing Lab, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Div Infect Dis, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 08期

关键词：

D O I：

10.1128/JVI.02596-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.

引用

页码：4180 / 4183

页数：4

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