The roles of Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: Ubiquity and diversity across the animal kingdom

被引：51

作者：

Picard, Marion Anne-Lise ^{[1
]}

Cosseau, Celine ^{[1
]}

Mouahid, Gabriel ^{[1
]}

Duval, David ^{[1
]}

Grunau, Christoph ^{[1
]}

Toulza, Eve ^{[1
]}

Allienne, Jean-Francois ^{[1
]}

Boissier, Jerome ^{[1
]}

机构：

[1] Univ Montpellier, IFREMER, CNRS, UMR 5244,IHPE,Univ Perpignan, F-66860 Perpignan, France

来源：

COMPTES RENDUS BIOLOGIES | 2015年 / 338卷 / 07期

关键词：

Dmrt genes; Gene expression pattern; Functional diversity; MOLECULAR-CLONING; DIMORPHIC EXPRESSION; DOMAIN GENE; DNA-BINDING; C-ELEGANS; GONADAL DIFFERENTIATION; GENOMIC ORGANIZATION; REVERSED GONADS; RANA-RUGOSA; MEDAKA;

D O I：

10.1016/j.crvi.2015.04.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes have been intensively studied because they represent major transcription factors in the pathways governing sex determination and differentiation. These genes have been identified in animal groups ranging from cnidarians to mammals, and some of the genes functionally studied. Here, we propose to analyze (i) the presence/absence of various Dmrt gene groups in the different taxa across the animal kingdom; (ii) the relative expression levels of the Dmrt genes in each sex; (iii) the specific spatial (by organ) and temporal (by developmental stage) variations in gene expression. This review considers non-mammalian animals at all levels of study (i.e. no particular importance is given to animal models), and using all types of sexual strategy (hermaphroditic or gonochoric) and means of sex determination (i.e. genetic or environmental). To conclude this global comparison, we offer an analysis of the DM domains conserved among the different DMRT proteins, and propose a general sex-specific pattern for each member of the Dmrt gene family. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：451 / 462

页数：12

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