Meta-analyses of clinical trials: are we getting lemonade from lemons?

被引：6
|
作者：
Bartels, Karsten [1 ,2 ]
Sessler, Daniel, I [2 ,3 ]
机构：
[1] Univ Nebraska Med Ctr, Dept Anesthesiol, Omaha, NE 68198 USA
[2] Outcomes Res Consortium, Cleveland, OH 44106 USA
[3] Cleveland Clin, Dept Outcomes Res, Cleveland, OH USA
来源：
BRITISH JOURNAL OF ANAESTHESIA | 2022年 / 128卷 / 02期
基金：
美国医疗保健研究与质量局; 美国国家卫生研究院;
关键词：
anaesthesia; bias; clinical trial methodology; meta-analysis; outcomes; postoperative pulmonary complications; rigour; PUBLICATION BIAS; CLONIDINE;
D O I：
10.1016/j.bja.2021.09.028
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Meta-analyses guide planning of clinical trials and clinical care, but are subject to all the methodologic problems and potential biases present in the underlying trials. Furthermore, publication bias often contributes to overestimated benefit in meta-analyses of small trials, which are often 'corrected' by subsequent large trials. Meta-analyses are no substitute for large robust trials.
引用
收藏
页码：233 / 235
页数：4
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