Association of the FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms with maternal body weight during pregnancy

被引:17
作者
Martins, Maisa Cruz [1 ,2 ]
Trujillo, Janet [1 ]
Farias, Dayana Rodrigues [1 ]
Struchiner, Claudio Jose [3 ]
Kac, Gilberto [1 ]
机构
[1] Univ Fed Rio de Janeiro, Nutr Epidemiol Observ, Dept Social & Appl Nutr, Inst Nutr Josue de Castro, Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Grad Program Nutr, Inst Nutr Josue de Castro, Rio De Janeiro, Brazil
[3] Fundacao Oswaldo Cruz, Natl Sch Publ Hlth, Rio De Janeiro, Brazil
关键词
Pregnancy; Weight gain; Weight retention; Polymorphism; Cohort study; MASS INDEX; COMMON VARIANTS; OBESITY; GAIN; ENERGY; RISK; ADIPOSITY; CHILDHOOD; RETENTION; VALIDITY;
D O I
10.1016/j.nut.2016.04.009
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: The fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) genes have been consistently associated with the risk for obesity, but few studies have examined the association of the obesity risk alleles with gestational outcomes. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) of the FTO (rs9939609) and MC4R (rs17782313) genes with changes in maternal body weight during pregnancy. Methods: A sample of 136 pregnant women were followed in a prospective cohort at 5 to 13, 20 to 26, and 30 to 36 wk gestation and 30 to 45 d postpartum. SNPs were analyzed by real-time polymerase chain reaction. Associations between polymorphisms and the outcomes were investigated through longitudinal linear mixed-effects models, multiple linear regression models, and Poisson regression models. Results: An SNP in the FTO (rs9939609) gene but not in the MC4R (rs17782313) gene was significantly associated with prepregnancy body mass index (BMI) >= 25 kg/m(2) (relative risk(FTO) = 2.1; 95% confidence interval [CI], 1.4-3.1). SNPs were not statistically associated with excessive gestational weight gain (GWG) or postpartum weight retention (PPWR). For the FTO (rs9939609) gene, women with the AA genotype were heavier in the body weight trajectory of pregnancy, but not when their weight had been adjusted for prepregnancy BMI (beta(FTO) = 0.5 kg; 95% CI, -1.9 to 3). These women started pregnancy heavier but gained less weight (FTO*gestational age = -0.1; 95% CI, -0.2 to 0.03) compared with those who had at least one T allele. Conclusions: The FTO (rs9939609) AA genotype is positively associated with prepregnancy excessive weight. We found no evidence of a significant effect of the MC4R (rs17782313) or the FTO (rs9939609) gene polymorphisms on the GWG and PPWR. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:1223 / 1230
页数:8
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