Genetic events in the pathogenesis of multiple myeloma

被引：145

作者：

Chng, W. J. ^{[1
]}

Glebov, O. ^{[2
]}

Bergsagel, R. L. ^{[1
]}

Kuehl, W. M. ^{[3
]}

机构：

[1] Mayo Clin, Scottsdale, AZ 85259 USA

[2] Natl Canc Inst, Bethesda, MD USA

[3] Natl Canc Inst, Genet Branch, Mol Pathogenesis Myeloma Sect, Bethesda, MD USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2007年 / 20卷 / 04期

关键词：

genetics; gene expression profiling; molecular pathogenesis; prognosis; IgH translocations; hyperdiploid;

D O I：

10.1016/j.beha.2007.08.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The genetics of myeloma has been increasingly elucidated in recent years. Recurrent genetic events, and also biologically distinct and clinically relevant genetic subtypes of myeloma have been defined. This has facilitated our understanding of the molecular pathogenesis of the disease. In addition, some genetic abnormalities have proved to be highly reproducible prognostic factors. With the expanding therapeutic armamentarium, it is time to include genetic assessment as part of clinical evaluation of myeloma patients to guide management. In this review we examine the role of various genetic abnormalities in the molecular pathogenesis of myeloma, and the use of such abnormalities in disease classification, prognosis and clinical management.

引用

页码：571 / 596

页数：26

共 108 条

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