Structure of neurofilaments studied with scanning tunneling microscopy

被引：17

作者：

Liu, J

Tong, XJ

Pang, SJ

Zhai, ZH ^{[1
]}

机构：

[1] Beijing Univ, Coll Life Sci, Beijing 100871, Peoples R China

[2] Chinese Acad Sci, Inst Phys, Ctr Condensed Matter Phys, Beijing Lab Vacuum Phys, Beijing 100080, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 1998年 / 43卷 / 21期

关键词：

neurofilament; intermediate filament; scanning tunneling microscopy;

D O I：

10.1007/BF02883377

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurofilaments (NFs) were isolated from bovine spinal cord. The structure of purified NFs was studied by scanning tunneling microscopy (STM). The STM images showed that NF was composed of a long core filament and numerous sidearms flanking the rod regularly. The diameter of the rod was about 10 nm (10.2 +/- 0.8 nm). Most of the sidearms were short and the distance between two adjacent sidearms was approximately 10 nm. There were some long sidearms between two proximal core filaments. The distance between two adjacent long sidearms was 21 nm. A three-quarter-staggered fashion of native NF structure was put forward.

引用

页码：1805 / 1809

页数：5

共 7 条

[1]

Carpenter DA, 1996, J CELL SCI, V109, P2493

[2] THE ROD DOMAIN OF NF-L DETERMINES NEUROFILAMENT ARCHITECTURE, WHEREAS THE END DOMAINS SPECIFY FILAMENT ASSEMBLY AND NETWORK FORMATION [J].