Dietary L-cysteine inhibits D-galactosamine-induced acute liver injury in rats

被引：5

作者：

Lee, Seulki ^{[1
]}

Han, Kyu-Ho ^{[1
,2
]}

Yabuki, Erina ^{[2
]}

Nakamura, Yumi ^{[2
]}

Kawakami, Sakura ^{[2
]}

Shimada, Kenichiro ^{[2
]}

Hayakawa, Toru ^{[3
]}

Onoue, Hirotake ^{[4
]}

Fukushima, Michihiro ^{[1
,2
]}

机构：

[1] Iwate Univ, Dept Bioresources Sci, United Grad Sch Agr Sci, Morioka, Iwate 0208550, Japan

[2] Obihiro Univ Agr & Vet Med, Dept Food Sci, Obihiro, Hokkaido 0808555, Japan

[3] Obihiro Univ Agr & Vet Med, Dept Anim & Food Hyg, Obihiro, Hokkaido 0808555, Japan

[4] Tomo Chem Co Ltd, Tokyo 1020082, Japan

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2015年 / 24卷 / 03期

关键词：

antioxidant; L-cysteine; rat; D-galactosamine; gluthathione; INDUCED OXIDATIVE STRESS; N-ACETYLCYSTEINE; MITOCHONDRIAL GLUTATHIONE; CARBON-TETRACHLORIDE; LIPID-PEROXIDATION; DAMAGE; ACID; ENZYME; HEPATOTOXICITY; HEPATOCYTES;

D O I：

10.1007/s10068-015-0147-3

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effects of l-cysteine (1 and 2%) on the antioxidative system were examined in rats with d-galactosamine (d-GalN)-induced injury. These rats showed increases in serum antioxidative enzyme and hepatic thiobarbituric acid reactive substances (TBARS) activities, with decreased hepatic/serum glutathione (GSH) levels and GSH-related enzyme activities. However, l-cysteine supplementation resulted in a decrease of hepatic TBARS levels, and increased catalase and serum GSH levels. The activities of serum enzymes in rats receiving 2% l-cysteine were significantly (p < 0.05) lower than in d-GalN-injected group rats, and similar to levels in control group rats without acute liver injury. In addition, 2% l-cysteine increased the glutathione reductase activity and decreased the serum TBARS level in liver injury group rats. Dietary l-cysteine, especially at a 2% level, exerts a hepatoprotective effect by alteration of the GSH level and antioxidative enzyme activities.

引用

页码：1151 / 1157

页数：7

共 44 条

[1] Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol [J].

AlMustafa, ZH ;

AlAli, AK ;

Qaw, FS ;

AbdulCader, Z .

TOXICOLOGY, 1997, 121 (03) :223-228

[2]

[Anonymous], 1974, Catalase. Methods Enzym. Anal., DOI DOI 10.1016/B978-0-12-091302-2.50032-3

[3]

[Anonymous], Guide for the care and use of laboratory animals, V8th

[4]

Awe S., 2011, Journal of Toxicology and Environmental Health Sciences, V3, P31

[5] Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance [J].

Blouet, Clemence ;

Mariotti, Francois ;

Azzout-Marniche, Dalila ;

Mathe, Veronique ;

Mikogami, Takashi ;

Tome, Daniel ;

Huneau, Jean-Francois .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (07) :1089-1097

[6]

Bostwick DG, 2000, CANCER, V89, P123, DOI 10.1002/1097-0142(20000701)89:1<123::AID-CNCR17>3.0.CO

[7]

2-9

[8] EFFECT OF N-ACETYLCYSTEINE ON PLASMA CYSTEIN AND GLUTATHIONE FOLLOWING PARACETAMOL ADMINISTRATION [J].

BURGUNDER, JM ;

VARRIALE, A ;

LAUTERBURG, BH .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (02) :127-131

[9] Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis [J].

Chalasani, N ;

Deeg, MA ;

Crabb, DW .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2004, 99 (08) :1497-1502

[10]

Choi Sanghoon, 2011, [Journal of Food Hygiene and Safety, 한국식품위생안전성학회지], V26, P235

← 1 2 3 4 5 →