Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids

被引：27

作者：

Dobson, Luca S. ^{[1
]}

Pattison, Graham ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 74期

关键词：

ALKENE HYBRID LIGANDS; ARYL BORONIC ACIDS; ASYMMETRIC ARYLATION; TRIFLUOROMETHYL KETONES; DIFLUOROMETHYL GROUP; CONJUGATE ADDITION; CYCLIC KETIMINES; ALPHA-KETOESTERS; 1,2-ADDITION; CYCLIZATION;

D O I：

10.1039/c6cc05775f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Rh-catalyzed arylation of fluorinated ketones with boronic acids is reported. This efficient process allows access to fluorinated alcohols in high yields under mild conditions. Competition experiments suggest that difluoromethyl ketones are more reactive than trifluoromethyl ketones in this process, despite their decreased electronic activation, an effect we postulate to be steric in origin.

引用

页码：11116 / 11119

页数：4

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