Highly regio- and enantioselective asymmetric hydroformylation of olefins mediated by 2,5-disubstituted phospholane ligands

被引：126

作者：

Axtell, AT

Cobley, CJ

Klosin, J

Whiteker, GT

Zanotti-Gerosa, A

Abboud, KA

机构：

[1] Chirotech Tech Ltd, Dowpharma, Cambridge CB4 0WG, England

[2] Dow Chem Co USA, Chem Sci, S Charleston, WV 25303 USA

[3] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[4] Dow Chem Co USA, Chem Sci, Midland, MI 48674 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 36期

关键词：

asymmetric catalysis; hydroformylation; P ligands; rhodium;

D O I：

10.1002/anie.200501478

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Off the shelf: The commercially available ligand (R,R)-1,2-bis(2,5-diphenylphospholano)ethane ((R,R)-Ph-bpe) has been identified as an excellent ligand for asymmetric hydroformylation. State-of-the-art regio- and enantioselectivities are obtained for reactions with styrene, allyl cyanide, and vinyl acetate as substrates while high reaction rates (> 4000 turnovers h-1) are maintained (see scheme; Ac = acetate, b/l = branched/linear). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5834 / 5838

页数：5

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