Catalytic Asymmetric Vinylogous Mukaiyama-aldol (CAVM) reactions: The enolate activation

被引：58

作者：

Bluet, G ^{[1
]}

Campagne, JM ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 12期

关键词：

D O I：

10.1021/jo015567s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Catalytic Asymmetric Vinylogous Mukaiyama (CAVM) reactions of various aldehydes with dienolate 1 using different enolate activations (CuF . (S)-TolBinBp, t-BuOCu . (S)-Tol-Binap, and various chiral nonracemic ammonium fluorides derived from cinchona alkaloids) are described. These reactions proved to be highly regioselective leading exclusively to the cr-aldol products in good yields and peer to good enantioselectivities.

引用

页码：4293 / 4298

页数：6

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