Co-administration of melatonin reverses the Tin-protoporphyrin (SnPP) induced decline of Cytochrome P450 content in vivo in rats

被引：3

作者：

Chandra, R ^{[1
]}

Upadhyaya, G ^{[1
]}

Dass, SK ^{[1
]}

Jain, R ^{[1
]}

机构：

[1] Univ Delhi, Dr B R Ambedkar Ctr Biomed Res, Delhi 110007, India

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 2000年 / 25卷 / 3-4期

关键词：

melatonin; tin-protoporphyrin; cytochrome P-450; glutathione S-transferase; reduced glutathione; heme oxygenase; biliverdin reductase; delta-aminolevulinic acid synthase;

D O I：

10.1007/BF03192316

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Melatonin (N-acetyl-5 methoxytryptamine) is a low molecular weight antioxidant and is an endogeneous defence system against the deleterious actions of the extremely reactive hydroxyl radical. Among the enzymes that participate in the antioxidant functions is cytochrome P-450, a stalwart of the detoxification system in the body. Our results revealed that tin-protoporphyrin administration brought about a marked decline in cytochrome P-450 levels. This decline was, however, reversed by the coadministration of the antioxidant, melatonin. Thus, the enhanced antioxidant status in melatonin-treated rats may act as a protective mediator of various pharmacological functions altered during tin-protoporphyrin (an antihyperbilirubemenic agent) administration to Wistar rats.

引用

页码：213 / 218

页数：6

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