In this research, nanofluid heat transfer enhancement in a pipe by means of twisted tape with alternate axis is presented. Finite volume method is selected as simulation tool. Influences of revolution angle and Reynolds number on nanofluid hydrothermal treatment have been demonstrated. Suitable formulas for Nusselt number and Darcy factor are provided. Results prove that temperature gradient augments with enhance of revolution angle because of increase in secondary flow but pressure loss augments with rise of revolution angle.