Concepts, technologies, and practices for drug delivery past the blood-brain barrier to the central nervous system

被引：61
作者：
Crawford, Lindsey [1 ]
Rosch, Justin [1 ]
Putnam, David [1 ,2 ]
机构：
[1] Cornell Univ, Sch Chem & Biomol Engn, Ithaca, NY 14853 USA
[2] Cornell Univ, Meinig Sch Biomed Engn, Ithaca, NY 14853 USA
来源：
JOURNAL OF CONTROLLED RELEASE | 2016年 / 240卷
基金：
美国国家科学基金会;
关键词：
Blood brain barrier; CNS delivery; CONVECTION-ENHANCED DELIVERY; SOLID LIPID NANOPARTICLES; RABIES VIRUS GLYCOPROTEIN; PEGYLATED LIPOSOMAL DOXORUBICIN; FOCUSED-ULTRASOUND DISRUPTION; DUAL-FUNCTIONAL NANOPARTICLES; CONJUGATED PLGA NANOPARTICLES; ISCHEMIA-REPERFUSION INJURY; IRON-OXIDE NANOPARTICLES; IN-VIVO;
D O I：
10.1016/j.jconrel.2015.12.041
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
While neurodegenerative diseases and cancers are on the rise, treatments for diseases of the central nervous system (CNS) remain limited. The blood brain barrier (BBB) poses the greatest challenge to CNS drug delivery and has therefore been a primary focus in the development of novel CNS drug delivery techniques. Limitations set by the BBB include molecule size, polarity, substrate specificity, and active efflux mechanisms. Strategies to overcome these challenges include drug delivery systems in conjunction with other chemical and physical targeting or BBB disruption mechanisms. This review outlines and describes the recent strategies employed to overcome challenges of drug delivery to the CNS while providing insight into promising techniques for future work. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：251 / 266
页数：16
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