Ligand-Free Copper-Catalyzed Regioselective C-2 Arylation of Imidazo[2,1-b]thiazoles

被引：47

作者：

Huang, Guoli ^{[1
]}

Sun, Hongsheng ^{[1
]}

Qiu, Xiaojie ^{[1
,2
]}

Jin, Can ^{[1
]}

Lin, Chen ^{[1
]}

Shen, Yingzhong ^{[2
]}

Jiang, Juli ^{[1
]}

Wang, Leyong ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Inst Chem Biol & Drug Innovat, Key Lab Mesoscop Chem,MOE, Nanjing 210093, Peoples R China

[2] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 19期

关键词：

H BOND ACTIVATION; ROOM-TEMPERATURE; PHOSPHINE-FREE; PALLADIUM; HETEROARENES; HETEROCYCLES; FUNCTIONALIZATION; (HETERO)ARENES; ALKENYLATION; DERIVATIVES;

D O I：

10.1021/ol2021109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective, regioselective C-2 arylation of imidazo[2,1-b]thiazoles catalyzed by Cu(I) has been developed. This arylation proceeded smoothly without promotion of the ligands, and various functional (22 samples) groups were well tolerated. Preliminary mechanistic studies of this arylation are also reported.

引用

页码：5224 / 5227

页数：4

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