Inhibition of D-Amino Acid Oxidase Activity by Antipsychotic Drugs Evaluated by a Fluorometric Assay Using D-Kynurenine as Substrate

被引：14

作者：

Iwasa, Sumiko ^{[1
]}

Tabara, Hiroshi ^{[1
]}

Song, Ziyu ^{[1
]}

Nakabayashi, Moe ^{[1
]}

Yokoyama, Yuusaku ^{[2
]}

Fukushima, Takeshi ^{[1
]}

机构：

[1] Toho Univ, Dept Analyt Chem, Fac Pharmaceut Sci, Chiba 2748510, Japan

[2] Toho Univ, Dept Synthet Organ Chem, Fac Pharmaceut Sci, Chiba 2748510, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2011年 / 131卷 / 07期

基金：

日本学术振兴会;

关键词：

D-amino acid oxidase; antipsychotic drug; fluorescence; D-kynurenine; RECEPTOR HYPOFUNCTION HYPOTHESIS; D-SERINE; IN-VITRO; SCHIZOPHRENIA; CHLORPROMAZINE; BRAIN; DAAO; NEUROTRANSMISSION; DISCOVERY; RACEMASE;

D O I：

10.1248/yakushi.131.1111

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine, sulpiride, quetiapine, and imipramine. CPZ inhibited DAAO (65.8 +/- 13.2 mu M, n=3) as reported previously, and other drugs also inhibited DAAO activity. Among these, quetiapine had the smallest IC50 value (19.5 +/- 2.60 mu M, n=3). The proposed assay can be useful for the evaluation or screening of DAAO-inhibitory drugs.

引用

页码：1111 / 1116

页数：6

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