Inhibition of D-Amino Acid Oxidase Activity by Antipsychotic Drugs Evaluated by a Fluorometric Assay Using D-Kynurenine as Substrate

被引：14
|
作者：
Iwasa, Sumiko [1 ]
Tabara, Hiroshi [1 ]
Song, Ziyu [1 ]
Nakabayashi, Moe [1 ]
Yokoyama, Yuusaku [2 ]
Fukushima, Takeshi [1 ]
机构：
[1] Toho Univ, Dept Analyt Chem, Fac Pharmaceut Sci, Chiba 2748510, Japan
[2] Toho Univ, Dept Synthet Organ Chem, Fac Pharmaceut Sci, Chiba 2748510, Japan
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2011年 / 131卷 / 07期
基金：
日本学术振兴会;
关键词：
D-amino acid oxidase; antipsychotic drug; fluorescence; D-kynurenine; RECEPTOR HYPOFUNCTION HYPOTHESIS; D-SERINE; IN-VITRO; SCHIZOPHRENIA; CHLORPROMAZINE; BRAIN; DAAO; NEUROTRANSMISSION; DISCOVERY; RACEMASE;
D O I：
10.1248/yakushi.131.1111
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine, sulpiride, quetiapine, and imipramine. CPZ inhibited DAAO (65.8 +/- 13.2 mu M, n=3) as reported previously, and other drugs also inhibited DAAO activity. Among these, quetiapine had the smallest IC50 value (19.5 +/- 2.60 mu M, n=3). The proposed assay can be useful for the evaluation or screening of DAAO-inhibitory drugs.
引用
收藏
页码：1111 / 1116
页数：6
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