Effects of taurine on hepatic lipid metabolism and anti-inflammation in chronic alcohol-fed rats

被引：20

作者：

Chou, Chung-Hsi ^{[2
,3
]}

Chang, Yuan-Yen ^{[4
,5
,6
]}

Tzang, Bor-Show ^{[6
,7
]}

Hsu, Chin-Lin ^{[8
]}

Lin, Yi-Ling ^{[7
]}

Lin, Hui-Wen ^{[9
]}

Chen, Yi-Chen ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Zoonoses Res Ctr, Taipei 106, Taiwan

[3] Natl Taiwan Univ, Sch Vet Med, Taipei 106, Taiwan

[4] Chung Shan Med Univ, Dept Microbiol & Immunol, Sch Med, Taichung 402, Taiwan

[5] Chung Shan Med Univ, Inst Microbiol & Immunol, Taichung 402, Taiwan

[6] Chung Shan Med Univ Hosp, Clin Lab, Taichung 402, Taiwan

[7] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung 402, Taiwan

[8] Chung Shan Med Univ, Sch Nutr, Taichung 402, Taiwan

[9] Natl Chung Hsing Univ, Dept Vet Med, Taichung 402, Taiwan

来源：

FOOD CHEMISTRY | 2012年 / 135卷 / 01期

关键词：

Alcohol; Liver damage; Lipid metabolism; Thiobarbituric acid reactive substances; Matrix metalloproteinases; Trolox equivalent antioxidant capacity; ACUTE LIVER-INJURY; ANTRODIA-CAMPHORATA; FLAXSEED OIL; FATTY LIVER; CONSUMPTION; PREVENTS; PROTECTS; FIBROSIS;

D O I：

10.1016/j.foodchem.2012.04.036

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The effects of taurine (Tau) in regulation of lipid metabolism and decreasing inflammation in chronic alcohol-fed rats was investigated. Rats were randomly divided into three groups: (1) isocaloric solution; (2) 3 g alcohol/kg BW/day; (3) 3 g alcohol/kg BW/day + 1 g Tau/kg BW/day for 6 weeks. Liver size and serum/liver lipids of alcohol-fed rats were decreased (p < 0.05) by Tau supplementation, but daily fecal lipid/bile acid outputs were increased (p < 0.05). Regarding de nova lipogenesis, Tau downregulated (p < 0.05) fatty-acid biosynthesis and upregulated (p < 0.05) cholesterol metabolism (CYP7A1) and energy expenditure (PPAR-alpha). Serum AST and ALT, and hepatic TNF-alpha levels and MMP-9 activity of alcohol-fed rats were decreased (p < 0.05) by Tau supplementation which may be related to the maintenance of higher (p < 0.05) antioxidant levels (lower thiobarbituric-acid-reactive-substances values and higher trolox equivalent antioxidant capacity) in serum and livers. Our study indicates that Tau downregulates lipogenesis, oxidative stress, and inflammation in chronic alcohol-fed rats. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：24 / 30

页数：7

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