Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy

被引：33

作者：

Chow, Tiffany W. ^{[1
,2
,4
]}

Izenberg, Aaron ^{[1
]}

Binns, Malcolm A. ^{[4
]}

Freedman, Morris ^{[1
,3
,4
]}

Stuss, Donald T. ^{[1
,3
,4
]}

Scott, Chris J. M. ^{[5
]}

Ramirez, Joel ^{[3
,5
]}

Black, Sandra E. ^{[1
,3
,5
]}

机构：

[1] Univ Toronto, Dept Med, Div Neurol, Toronto, ON M5S 1A1, Canada

[2] Univ Toronto, Dept Psychiat, Div Geriatr Psychiat, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Dept Psychol, Inst Med Sci, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Sunnybrook Hlth Sci Ctr, Baycrest Div Neurol, Rotman Res Inst, Toronto, ON, Canada

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Neurol, Toronto, ON, Canada

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2008年 / 26卷 / 01期

关键词：

basal ganglia; frontotemporal dementia; frontotemporal lobar degeneration; thalamus;

D O I：

10.1159/000144028

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: The clinical syndrome of the frontotemporal dementias (FTD) overlaps with frontal-subcortical circuit syndromes. We explored the extent to which subcortical atrophy on structural magnetic resonance imaging may indicate a subcortical contribution to the progression of FTD. Methods: This cross-sectional case-control study compared striatal and thalamic gray matter volumes and functional levels from 30 FTD cases and 30 age- and gender-matched controls. Results: The FTD group had significantly more atrophy in all gray matter subcortical regions, correlating with ipsilateral frontocortical atrophy. Subcortical atrophy was also associated with functional disability. Subcortical asymmetry was most marked in subjects with primary progressive aphasia. Conclusion: Subcortical gray matter atrophy may contribute as significantly to symptoms of FTD as cortical atrophy. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：79 / 88

页数：10

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