Prokaryotic ParA-ParB-parS system links bacterial chromosome segregation with the cell cycle

被引：56
作者：
Mierzejewska, Jolanta [1 ]
Jagura-Burdzy, Grazyna [1 ]
机构：
[1] PAS, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
来源：
PLASMID | 2012年 / 67卷 / 01期
关键词：
parABS; Chromosome segregation; Bacteria; Cell cycle; STREPTOMYCES-COELICOLOR A3(2); VIBRIO-CHOLERAE CHROMOSOMES; ESCHERICHIA-COLI CHROMOSOME; BACILLUS-SUBTILIS CHROMOSOME; DNA-REPLICATION INITIATION; PROTEIN SPO0J PARB; PLASMID SEGREGATION; CAULOBACTER-CRESCENTUS; PSEUDOMONAS-AERUGINOSA; PARTITIONING PROTEINS;
D O I：
10.1016/j.plasmid.2011.08.003
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
While the essential role of episomal par loci in plasmid DNA partitioning has long been appreciated, the function of chromosomally encoded par loci is less clear. The chromosomal parA-parB genes are conserved throughout the bacterial kingdom and encode proteins homologous to those of the plasmidic Type I active partitioning systems. The third conserved element, the centromere-like sequence called pars, occurs in several copies in the chromosome. Recent studies show that the ParA-ParB-parS system is a key player of a mitosis-like process ensuring proper intracellular localization of certain chromosomal regions such as oriC domain and their active and directed segregation. Moreover, the chromosomal par systems link chromosome segregation with initiation of DNA replication and the cell cycle. (C) 2011 Elsevier Inc. All rights reserved.
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页码：1 / 14
页数：14
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