Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

被引：51

作者：

Kageji, T. ^{[1
]}

Mizobuchi, Y. ^{[1
]}

Nagahiro, S. ^{[1
]}

Nakagawa, Y. ^{[2
]}

Kumada, H. ^{[3
]}

机构：

[1] Kagawa Natl Childrens Hosp, Dept Neurosurg, Kagawa, Japan

[2] Univ Tokushima, Dept Neurosurg, Tokushima 770, Japan

[3] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Radiat Oncol, Ibaraki, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2011年 / 69卷 / 12期

关键词：

BNCT; Glioblastoma; Survival; EPITHERMAL-NEUTRON; MALIGNANT GLIOMA; RADIATION-INJURY; BRAIN-TUMOR; BEAMS;

D O I：

10.1016/j.apradiso.2011.05.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998. The median survival time (MST) of BNCT was 19.5 months, and 2-year, 3-year and 5-year survival rates were 26.1%, 17.4% and 5.8%, respectively. This clinical result of BNCT in patients with GBM is superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1823 / 1825

页数：3

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