Biology and Mechanisms of Action of the Vitamin D Hormone

被引：203

作者：

Pike, J. Wesley ^{[1
]}

Christakos, Sylvia ^{[2
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Biochem Addit, Room 543D,433 Babcock Dr, Madison, WI 53706 USA

[2] Rutgers State Univ, New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, 185 South Orange Ave, Newark, NJ 07103 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 04期

关键词：

Mineral homeostasis; Calcemic hormones; Transcription; Target genes; RANKL; Transient receptor potential vanilloid type-6 (TRPV6); Genome-wide principles; Genetic linkage; 25-HYDROXYVITAMIN D-3 24-HYDROXYLASE; D-DEPENDENT RICKETS; INTESTINAL CALCIUM-ABSORPTION; D-RESPONSIVE ELEMENT; ENHANCER-PROMOTER INTERACTIONS; POTENTIAL VANILLOID TYPE-6; RECEPTOR CHROMOSOMAL GENE; HUMAN OSTEOCALCIN GENE; 1,25-DIHYDROXYVITAMIN D-3; OSTEOCLAST DIFFERENTIATION;

D O I：

10.1016/j.ecl.2017.07.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The central role of hormonal 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D-mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

引用

页码：815 / +

页数：30

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