Biology and Mechanisms of Action of the Vitamin D Hormone

被引：203

作者：

Pike, J. Wesley ^{[1
]}

Christakos, Sylvia ^{[2
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Biochem Addit, Room 543D,433 Babcock Dr, Madison, WI 53706 USA

[2] Rutgers State Univ, New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, 185 South Orange Ave, Newark, NJ 07103 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 04期

关键词：

Mineral homeostasis; Calcemic hormones; Transcription; Target genes; RANKL; Transient receptor potential vanilloid type-6 (TRPV6); Genome-wide principles; Genetic linkage; 25-HYDROXYVITAMIN D-3 24-HYDROXYLASE; D-DEPENDENT RICKETS; INTESTINAL CALCIUM-ABSORPTION; D-RESPONSIVE ELEMENT; ENHANCER-PROMOTER INTERACTIONS; POTENTIAL VANILLOID TYPE-6; RECEPTOR CHROMOSOMAL GENE; HUMAN OSTEOCALCIN GENE; 1,25-DIHYDROXYVITAMIN D-3; OSTEOCLAST DIFFERENTIATION;

D O I：

10.1016/j.ecl.2017.07.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The central role of hormonal 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D-mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

引用

页码：815 / +

页数：30

共 184 条

[1] Evidence for a Role of Prolactin in Calcium Homeostasis: Regulation of Intestinal Transient Receptor Potential Vanilloid Type 6, Intestinal Calcium Absorption, and the 25-Hydroxyvitamin D3 1α Hydroxylase Gene by Prolactin [J].

Ajibade, Dare V. ;

Dhawan, Puneet ;

Fechner, Adam J. ;

Meyer, Mark B. ;

Pike, J. Wesley ;

Christakos, Sylvia .

ENDOCRINOLOGY, 2010, 151 (07) :2974-2984

[2] Mutation of the CYP2R1 Vitamin D 25-Hydroxylase in a Saudi Arabian Family with Severe Vitamin D Deficiency [J].

Al Mutair, Angham N. ;

Nasrat, Ghada H. ;

Russell, David W. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (10) :E2022-E2025

[3] Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses [J].

Amling, M ;

Priemel, M ;

Holzmann, T ;

Chapin, K ;

Rueger, JM ;

Baron, R ;

Demay, MB .

ENDOCRINOLOGY, 1999, 140 (11) :4982-4987

[4] Epigenetic protein families: a new frontier for drug discovery [J].

Arrowsmith, Cheryl H. ;

Bountra, Chas ;

Fish, Paul V. ;

Lee, Kevin ;

Schapira, Matthieu .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (05) :384-400

[5] CLONING AND EXPRESSION OF FULL-LENGTH CDNA-ENCODING HUMAN VITAMIN-D RECEPTOR [J].

BAKER, AR ;

MCDONNELL, DP ;

HUGHES, M ;

CRISP, TM ;

MANGELSDORF, DJ ;

HAUSSLER, MR ;

PIKE, JW ;

SHINE, J ;

OMALLEY, BW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (10) :3294-3298

[6] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k [J].

Benn, Bryan S. ;

Ajibade, Dare ;

Porta, Angela ;

Dhawan, Puneet ;

Hediger, Matthias ;

Peng, Ji-Bin ;

Jiang, Yi ;

Oh, Goo Taeg ;

Jeung, Eui-Bae ;

Lieben, Liesbet ;

Bouillon, Roger ;

Carmeliet, Geert ;

Christakos, Sylvia .

ENDOCRINOLOGY, 2008, 149 (06) :3196-3205

[7] The NIH Roadmap Epigenomics Mapping Consortium [J].

Bernstein, Bradley E. ;

Stamatoyannopoulos, John A. ;

Costello, Joseph F. ;

Ren, Bing ;

Milosavljevic, Aleksandar ;

Meissner, Alexander ;

Kellis, Manolis ;

Marra, Marco A. ;

Beaudet, Arthur L. ;

Ecker, Joseph R. ;

Farnham, Peggy J. ;

Hirst, Martin ;

Lander, Eric S. ;

Mikkelsen, Tarjei S. ;

Thomson, James A. .

NATURE BIOTECHNOLOGY, 2010, 28 (10) :1045-1048

[8] Vitamin D and the skin [J].

Bikle, Daniel D. .

JOURNAL OF BONE AND MINERAL METABOLISM, 2010, 28 (02) :117-130

[9] VITAMIN-D, CALCIUM, AND EPIDERMAL DIFFERENTIATION [J].

BIKLE, DD ;

PILLAI, S .

ENDOCRINE REVIEWS, 1993, 14 (01) :3-19

[10] Transcriptional Regulation of the Human TNFSF11 Gene in T Cells Via A Cell Type-Selective Set of Distal Enhancers [J].

Bishop, Kathleen A. ;

Wang, Xiaohua ;

Coy, Heidi M. ;

Meyer, Mark B. ;

Gumperz, Jenny E. ;

Pike, J. Wesley .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2015, 116 (02) :320-330

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