Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study

被引:11
作者
Adomako-Ankomah, Yaw [1 ]
Chenoweth, Matthew S. [1 ]
Tocker, Aaron M. [1 ]
Doumbia, Saibou [2 ]
Konate, Drissa [2 ]
Doumbouya, Mory [2 ]
Keita, Abdoul S. [2 ]
Anderson, Jennifer M. [1 ]
Fairhurst, Rick M. [1 ]
Diakite, Mahamadou [2 ]
Miura, Kazutoyo [1 ]
Long, Carole A. [1 ]
机构
[1] NIAID, NIH, Lab Malaria & Vector Res, Rockville, MD 20852 USA
[2] Univ Sci Tech & Technol Bamako, Malaria Res & Training Ctr, Fac Med Pharm & Odontostomatol, Bamako, Mali
基金
美国国家卫生研究院;
关键词
Plasmodium falciparum; Malaria; Gametocytes; Longitudinal; Multiclonality; Mali; ACQUIRED-IMMUNITY; BURKINA-FASO; MALARIA; CHILDREN; TRANSMISSION; INFECTION; CARRIAGE; EPIDEMIOLOGY; ELIMINATION; COMMUNITY;
D O I
10.1186/s12936-017-2123-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle. Thus, a better understanding of which individuals constitute the primary gametocyte reservoir within an endemic population, and the temporal dynamics of gametocyte carriage, especially in seasonal transmission settings, will not only support the effective implementation of current transmission control programmes, but also inform the design of more targeted strategies. Methods: A 1-year prospective cohort study was initiated in June 2013 with the goal of assessing the longitudinal dynamics of P. falciparum gametocyte carriage in a village in Mali with intense seasonal malaria transmission. A cohort of 500 individuals aged 1-65 years was recruited for this study. Gametocyte prevalence was measured monthly using Pfs25-specific RT-PCR, and analysed for the effects of host age and gender, seasonality, and multiclonality of P. falciparum infection over 1 year. Results: Most P. falciparum infections (51-89%) in this population were accompanied by gametocytaemia throughout the 1-year period. Gametocyte prevalence among P. falciparum-positive individuals (proportion of gametocyte positive infections) was associated with age (p = 0.003) but not with seasonality (wet vs. dry) or gender. The proportion of gametocyte positive infections were similarly high in children aged 1-17 years (74-82% on median among 5 age groups), while older individuals had relatively lower proportion, and those aged > 35 years (median of 43%) had significantly lower than those aged 1-17 years (p < 0.05). Plasmodium falciparum-positive individuals with gametocytaemia were found to have significantly higher P. falciparum multiclonality than those without gametocytaemia (p < 0.033 in two different analyses). Conclusions: Taken together, these results suggest that a substantial proportion of Pf-positive individuals carries gametocytes throughout the year, and that age is a significant determinant of gametocyte prevalence among these P. falciparum-positive individuals. Furthermore, the presence of multiple P. falciparum genotypes in an infection, a common feature of P. falciparum infections in high transmission areas, is associated with gametocyte prevalence.
引用
收藏
页数:8
相关论文
共 33 条
[1]   Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data [J].
Abdulla, Salim ;
Achan, Jane ;
Adam, Ishag ;
Alemayehu, Bereket H. ;
Allan, Richard ;
Allen, Elizabeth N. ;
Anvikar, Anupkumar R. ;
Arinaitwe, Emmanuel ;
Ashley, Elizabeth A. ;
Asih, Puji Budi Setia ;
Awab, Ghulam Rahim ;
Barnes, Karen I. ;
Bassat, Quique ;
Baudin, Elisabeth ;
Bjorkman, Anders ;
Bompart, Francois ;
Bonnet, Maryline ;
Borrmann, Steffen ;
Bousema, Teun ;
Carrara, Verena I. ;
Cenci, Fabio ;
Checchi, Francesco ;
Cot, Michel ;
Dahal, Prabin ;
D'Alessandro, Umberto ;
Deloron, Philippe ;
Djimde, Abdoulaye ;
Dondorp, Arjen ;
Dorsey, Grant ;
Doumbo, Ogobara K. ;
Drakeley, Chris J. ;
Duparc, Stephan ;
Espie, Emmanuelle ;
Faiz, Abul ;
Falade, Catherine O. ;
Fanello, Caterina ;
Faucher, Jean-Francois ;
Faye, Babacar ;
Filler, Scott ;
Fofana, Bakary ;
Fogg, Carole ;
Gansane, Adama ;
Gaye, Oumar ;
Genton, Blaise ;
Gething, Peter W. ;
Gonzalez, Raquel ;
Grandesso, Francesco ;
Greenwood, Brian ;
Grivoyannis, Anastasia ;
Guerin, Philippe J. .
BMC MEDICINE, 2016, 14
[2]   High Plasmodium falciparum longitudinal prevalence is associated with high multiclonality and reduced clinical malaria risk in a seasonal transmission area of Mali [J].
Adomako-Ankomah, Yaw ;
Chenoweth, Matthew S. ;
Durfee, Katelyn ;
Doumbia, Saibou ;
Konate, Drissa ;
Doumbouya, Mory ;
Keita, Abdoul S. ;
Nikolaeva, Daria ;
Tullo, Gregory S. ;
Anderson, Jennifer M. ;
Fairhurst, Rick M. ;
Daniels, Rachel ;
Volkman, Sarah K. ;
Diakite, Mahamadou ;
Miura, Kazutoyo ;
Long, Carole A. .
PLOS ONE, 2017, 12 (02)
[3]   Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study [J].
AlYaman, F ;
Genton, B ;
Reeder, JC ;
Anders, RF ;
Smith, T ;
Alpers, MP .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1997, 91 (05) :602-605
[4]   Plasmodium falciparum genotype and gametocyte prevalence in children with uncomplicated malaria in coastal Ghana [J].
Ayanful-Torgby, Ruth ;
Oppong, Akua ;
Abankwa, Joana ;
Acquah, Festus ;
Williamson, Kimberly C. ;
Amoah, Linda Eva .
MALARIA JOURNAL, 2016, 15
[5]   Gametocytes: insights gained during a decade of molecular monitoring [J].
Babiker, Hamza A. ;
Schneider, Petra ;
Reece, Sarah E. .
TRENDS IN PARASITOLOGY, 2008, 24 (11) :525-530
[6]   Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination [J].
Bousema, Teun ;
Drakeley, Chris .
CLINICAL MICROBIOLOGY REVIEWS, 2011, 24 (02) :377-+
[7]   High prevalence of Plasmodium falciparum gametocyte infections in school-age children using molecular detection: patterns and predictors of risk from a cross-sectional study in southern Malawi [J].
Coalson, Jenna E. ;
Walldorf, Jenny A. ;
Cohee, Lauren M. ;
Ismail, Miriam D. ;
Mathanga, Don ;
Cordy, Regina Joice ;
Marti, Matthias ;
Taylor, Terrie E. ;
Seydel, Karl B. ;
Laufer, Miriam K. ;
Wilson, Mark L. .
MALARIA JOURNAL, 2016, 15 :1-17
[8]   Sickle cell trait is associated with a delayed onset of malaria: Implications for time-to-event analysis in clinical studies of malaria [J].
Crompton, Peter D. ;
Traore, Boubacar ;
Kayentao, Kassoum ;
Doumbo, Safiatou ;
Ongoiba, Aissata ;
Diakite, Seidina A. S. ;
Krause, Michael A. ;
Doumtabe, Didier ;
Kone, Younoussou ;
Weiss, Greta ;
Huang, Chiung-Yu ;
Doumbia, Seydou ;
Guindo, Aldiouma ;
Fairhurst, Rick M. ;
Miller, Louis H. ;
Pierce, Susan K. ;
Doumbo, Ogobara K. .
JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (09) :1265-1275
[9]   A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking [J].
Daniels, Rachel ;
Volkman, Sarah K. ;
Milner, Danny A. ;
Mahesh, Nira ;
Neafsey, Daniel E. ;
Park, Daniel J. ;
Rosen, David ;
Angelino, Elaine ;
Sabeti, Pardis C. ;
Wirth, Dyann F. ;
Wiegand, Roger C. .
MALARIA JOURNAL, 2008, 7 (1)
[10]   Asymptomatic Carriage of Plasmodium in Urban Dakar: The Risk of Malaria Should Not Be Underestimated [J].
Diallo, Abdoulaye ;
Ndam, Nicaise Tuikue ;
Moussiliou, Azizath ;
Dos Santos, Stephanie ;
Ndonky, Alphousseyni ;
Borderon, Marion ;
Oliveau, Sebastien ;
Lalou, Richard ;
Le Hesran, Jean-Yves .
PLOS ONE, 2012, 7 (02)